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The project
The project
The overall objective was to ‘further develop generic PBK(D) models for different subgroups of the human population and animal life stages to support their use in food and feed safety assessment in a transparent manner’. It aimed to bring available information on PBK(D) model codes, physiological input parameters, and information on the expression of metabolic enzymes and transporters together in open source databases, together with information on gene and protein sequences and molecular modelling tools, allowing estimation of chemicals’ interactions with biotransformation enzymes and transporters, as well as comprehension of mechanistic basis of chemical-protein interaction. These tools were applied in case studies relevant for feed and food safety assessment.
Partners
Partners
Wageningen Food Safety Research (WFSR, The Netherlands), Institut national de l'environnement industriel et des risques (Ineris, France), Istituto Superiore di Sanità (ISS, Italy), Università degli Studi di Parma (UNIPR, Italy), Istituto di Ricerche Farmacologiche Mario Negri IRCCS (IRFMN, Italy), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES, France), and Rijksinstituut voor Volksgezondheid en Milieu (RIVM, The Netherlands)
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