COSMOS

The project

COSMOS was an FP7 European project, also funded by Cosmetics Europe, in the SEURAT-1 cluster.

The main aim of COSMOS was to develop freely available (open access and/or source) tools and workflows to predict the safety to humans following the use of cosmetic ingredients.

METO was mainly responsible for QSAR and PBPK modelling within COSMOS.

In particular, hepatoxicity and dynamics of a mixture of three cosmetic ingredients (coumarin, isoeugenol, and benzophenone-2) by studying cell viability via in vitro impedance data (Teng et al., 2015).

Ab initio modeling (PBPK and QSAR) was used in three case studies (methotrexate, valproic acid, and piperonyl butoxide) (Bois et al., 2017).

Publications

• • Bois FY, Ochoa JG, Gajewska M, Kovarich S, Mauch K, Paini A, Péry A, Benito JV, Teng S, Worth A. 2017. Multiscale modelling approaches for assessing cosmetic ingredients safety. Toxicology. Volume 392, pp 130-139.

  • De Sousa G., Teng S., Salle-Siri R., Pery A., Rahmani R. Prediction of the metabolic clearance of benzophenone-2, and its interaction with isoeugenol and coumarin using cryopreserved human hepatocytes in primary culture. Food and Chemical Toxicology, 2016, 90: p. 55-63.

  • Teng S, Barcellini-Couget S, Beaudouin R, Brochot C, Desousa G, Rahmani R, Pery A. BK/TD models for analyzing in vitro impedance data on cytotoxicity. 2015. Toxicology Letters. 235 (2): 96–106.