Former team members
Toxicokinetic modelling in risk assessment.
Physiologically based toxicokinetic modeling (PBPK models) to describe the fate of xenobiotics in living organisms (humans, rodents and fish) in order to (i) characterize the external dose-internal dose relationship, ie predict exposure of the active compound in the tissues targets; Or (ii) to estimate population exposures from biomonitoring data,
Development of models to improve analysis of in vitro experiments to extrapolate the results to in vivo situations, in particular on bio-artificial organs,
Development of statistical models to improve the analysis of toxicokinetic data and their use in risk assessment (analysis of sensitivity, uncertainty and variability).
From 2014 to 2022, she is the head of the unit “Models for ecotoxicology and toxicology” (METO) at INERIS.
Alexandre PERY graduated from the “Ecole Polytechnique” and the “Ecole National du Génie Rural des Eaux et des Forêts (ENGREF)”. He also obtained a master in toxicology (University Paris V) and a master in public economics (University Grenoble II). He has published around 50 ISI articles in the last 11 years (h-index of 11). He obtained his PhD in 2003 and his ability to supervise research (HDR) in 2006 in the field of modeling applied to ecotoxicology, when he was researcher in Cemagref (Lyon).
From 2008 to 2014, he is the head of the unit “Models for ecotoxicology and toxicology” (METO) at INERIS.
Frédéric Bois worked at Ineris from 1999 to 2019. His research focused on pharmacology, quantitative toxicology, epidemiology and risk assessment, with a strong emphasis on the development of mathematical or statistical models, and enabling software. In particular, Frédéric was involved in many research projects regarding systems biology modeling of metabolic and early toxicity pathways, replacement of animal experiments with combination of innovative mathematical modeling and in vitro assays (EU-ToxRisk, Euromix, StemBANCC, SEURAT/COSMOS,PREDICT-IV,DYSHORMO, ToxOnChip), PBPK modelling, population variability, microarray data analysis (ToxOnChip), Bayesian inference on graphs (with application to network structure inference) (project Prior-Motives), and the extension of PBPK modeling with systems biology models of metabolism and pharmacology or toxicity pathways.
Toxicological risk assesment of electromagnetic fields
Physics specialized in radiology (MRI)
Effects of RF on thermoregulation
Apprentice engineer
PhD students
Postdoctoral researchers
Dr. Cappelli Claudia-Ileana (2018 - 2019)
Dr. Nazanin Golbamaki-Bakhtyari
Dr. Nadia Quignot
Dr Aude Ratier (2021 - 2022)
Research assistants
Doris Tan
Nesrine Gharbi