Elisa Thépaut

The aim of this PhD thesis will be to establish an exposure assessment ranging from the prenatal to postnatal period to chemical substances in children of the Elfe cohort. This will include estimating fetal exposure to different families of substances such as pesticides but also phthalates or perfluorinated compounds. Estimates of internal exposure in targeted tissues will then be linked to available data on potential health effects in newborns and children. A first part of the PhD thesis will concern PBPK modeling during pregnancy and the postnatal period. Particular attention will be paid to the evolution of the metabolism in the fetus and young child. A second part will consist in using the PBPK models developed and the biomarker measurements carried out in the children of the Elfe cohort in order to predict the internal concentrations in the targeted tissues. Exposure data, particularly through food, may also be used to predict the internal exposure of substances for which no biomarker have been measured. In a final part, in utero exposure data will be compared with available data on potential health effects in newborns and children, in particular effects on neurodevelopment.