DEB models

A DEB model is a model based on the Dynamic Energy Budget (DEB) theory. The DEB theory (Kooijman, 2010) focuses on the allocation of energy within the organism and describes the physiological processes of an organism (food assimilation,maintenance, growth, puberty, reproduction) using mechanistic mathematical models. Consequently, a DEB model can describe the whole life cycle of an organism.

DEB model is used in ecotoxicology (DEBtox model) to describe the effects of pollutants on organisms. The DEB model is then coupled to a TK/TD model and it assumes that the effect on a parameter of the model appears when the internal toxic concentration exceeds a threshold called no effect concentration (NEC).

DEB and DEBtox models have already been developed for different organisms in METO such as crustacea (Massarin et al., 2011), worm (Goussen et al., 2015) and fish (Le Loutre et al., 2016 and David et al., 2018).

Key publications

- Massarin S.,Beaudouin R.,Zeman F., Floriani M., Gilbin R., Alonzo F., and Pery A. R. R. 2011. Biology-Based Modeling To Analyze Uranium Toxicity Data on Daphnia magna in a Multigeneration Study. Environmental Science & Technology 45:4151-4158.
- Goussen B., Beaudouin R., Dutilleul M., Buisset-Goussen A., Bonzom JM., Péry ARR. 2015. Energy-based modelling to assess effects of chemicals on Caenorhabditis elegans: A case study on uranium. Chemosphere. Volume 120, Pages 507–514.

Leloutre, C., Pery, A.R.R., Porcher, J.M., Beaudouin, R., 2018. A bioenergetics model of the entire life cycle of the three-spined stickleback, Gasterosteus aculeatus. Ecology of Freshwater Fish 27, 116-127.
David, V., Goussen, B., Tebby, C., Joachim, S., Porcher, J.M., Beaudouin, R., 2018. Modelling historical mesocosm data: application of a fish bioenergetics model in semi-natural conditions. Ecology of Freshwater Fish 27, 1101-1113.

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