Thomas Loret
Contact
INERIS, DRC/MIV/TEAM
Parc ALATA, BP 2
5, rue Taffanel
60550 Verneuil en Halatte, France
Research interests
My research focuses on the evaluation of the biological impact of materials, environmental pollutants, and complex mixtures after inhalation. I have a specific expertise on the assessment of adverse effects using in vivo and advanced in vitro methods, on in vivo/in vitro correlations and on bio-distribution/dosimetry/biodegradation.
Current and previous projects
1) Evaluating the toxicity and developing/validating innovative tools to study particles, chemicals, complex mixtures impact after inhalation (2023- )
2) Developing innovative tools to study the impact, biodistribution and mode of action of micro and nanoplastics on human health after inhalation or ingestion. (PLASTICHEAL, Horizon 2020, 2021-2023)
3) Validating methodology to assess 2D materials deposition, internalisation, toxicity in vitro. (2018-2022)
4) Evaluating the impact of exposures to graphene materials, graphene reinforced composites, other 2D materials and high aspect/ratio naterials on the lungs and immune system. (Graphene flagship project, Horizon 2020, 2018-2022)
5) Evaluating the toxicity of poorly soluble metallic particles using in vivo and advanced in vitro methods. (NANoREG, FP7, 2013-2017)
6) Evaluating the in vitro toxicity of formaldehyde after exposure at the air-liquid interface. (01/2013- 06/2013)
Education
2013-2017 PhD Toxicology, Compiegne University of technology (UTC), France
2007-2016 PharmD, University of Paris-Saclay, France
2012-2013 MRes Public Health and Environmental Risks, University of Paris-Saclay, France
Experience
2023- Researcher, Experimental Toxicology and Modelisation Unit, National institute for environmental and industrial risks (INERIS), France
2018-2023 Research Associate Experimental / Immuno Toxicology, Nanomedicine lab, Faculty of Biology, Medicine and Health, University of Manchester, UK
2013-17 PhD candidate Pulmonary Toxicology, Experimental toxicology unit, National institute for environmental and industrial risk (INERIS), France
2013 (6 months) Research trainee Environmental Toxicology, Environmental Epidemiology: Health impact of pollutions Unit, University of Paris, France
2012 (4 months) Trainee Health Risk Assessment, Direction of Health Safety and Management systems, ENGIE, France
2011-2012 Intern Pharmacy, Assistance Public des Hopitaux de Paris (APHP), France
Recent publications
Viana D, Walston S. T, Illa, X, del Valle J, Hayward A, Dodd A, Loret T,.. and Garrido J. A. Graphene-based thin film microelectrode technology for in vivo high resolution neural recording and stimulation. Nature Nanotechnology (2023). In press. biorxiv: doi.org/10.1101/2022.11.16.515761
Loret T, de Luna L. A. V, Lucherelli M. A, Fordham A, Drummond M, Esteban-Arranz A, Lozano N, Bianco A, Kostarelos K and Bussy C. Lung Persistence, Biodegradation, and Elimination of Graphene‐Based Materials are Predominantly Size‐Dependent and Mediated by Alveolar Phagocytes. Small. (2023). doi.org/10.1002/smll.202301201
De Luna, L. A. V^, Loret T^, Fordham, A., Arshad, A., Drummond, M., Dodd, A, Lozano N, Kostarelos K and Bussy C. Lung recovery from DNA damage induced by graphene oxide is dependent on size, dose and inflammation profile. Particle and Fibre Toxicology. (2022). Doi. 10.1186/s12989-022-00502-w
Loret T, Luis de Luna L. A. V, Fordham A, Arshad A, Barr K, Lozano N, Kostarelos K and Bussy C. Innate but Not Adaptive Immunity Regulates Lung Recovery from Chronic Exposure to Graphene Oxide Nanosheets. Advanced Science. (2022). doi.10.1002/advs.202104559
Chortarea S, Kuru O.C, Netkueakul W, Pelin M, Keshavan S, Song Z, Ma B, Gómez J, Villaro E, de Luna L. A. V, Loret T, Drummond M, Fordham A, Anagnostopoulos G, Paterakis G, Cataldi P, Tubaro A, Galiotis C, Kinloch I, Fadeel B, Bussy C, Kostarelos K, Buerki-Thurnherr T, Prato M, Bianco A and Wick P. Hazard assessment of abraded thermoplastic composites reinforced with reduced graphene oxide. Journal of Hazardous Materials. (2022). doi.10.1016/j.jhazmat.2022.129053
Chen Y, Auty J, Crica L, Barr K, Rosano V, Esteban Arranz A, Loret T, Spiller D, Bussy C, Kostarelos K, Vranic S. Dynamic interactions and intracellular fate of label-free, thin graphene oxide sheets within mammalian cells: role of lateral sheet size. Nanoscale advances. (2021). doi.10.1039/D1NA00133G
Franqui L. S, de Luna L. A. V, Loret T, Martinez D. S. T, and Bussy C. Assessing the Adverse Effects of Two-Dimensional Materials Using Cell Culture-Based Models. In Nanotechnology Characterization Tools for Environment, Health, and Safety. (2019). Springer. doi.10.1007/978-3-662-59600-5_1
Loret T, Rogerieux F, Trouiller B, Braun A, Egles C, Lacroix G. Predicting the in vivo pulmonary toxicity induced by acute exposure to poorly soluble nanomaterials by using advanced in vitro methods. Particle and Fibre Toxicology. (2018). doi.10.1186/s12989-018-0260-6
Lacroix G, Koch W, Ritter D, Gutleb A, Thor Larsen S, Loret T, Zanetti F, Constant , Chortaea S, Rothen-Ruthishauser B, Hiemstra P, Frejafon E, Hubert P, Gribaldo L, Kearns P, Aublant J-M, Diabate S, Weiss C, de Groot A, Kooter I. Air-liquid interface in vitro models for respiratory toxicology research: consensus workshop and recommendations. Applied In Vitro Toxicology (2018). doi: 10.1089/aivt.2017.0034