Ségolène Simeon

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PhD Project

Some chemical compounds can disrupt the endocrine system, causing reproductive and developmental dysfunctions. Potential endocrine disrupting compounds (EDs) adverse effects on humans and wildlife are a growing concern. Zebrafish are a highly used vertebrate in toxicology and ecotoxicology, and many ED toxicity data have been produced in recent years. The European project EU-ToxRisk brings international teams around replacing animal testing in toxicology with in vitro methods and mathematical models. In the project framework, the PhD objective is to develop mechanistic models of developmental and reproductive toxicity in zebrafish embryo (Danio rerio), and their simulations for predictive purposes, allowing to transpose to the human the results obtained in vitro.

Work experience

• • Nov 2017 – Nov 2020. Doctor of Philosophy candidate at INERIS. Unit Models for Ecotoxicology and Toxicology. Subject: “Systemic mathematical modeling of reproductive and developmental toxicity of zebrafish”. Under the direction of Frédéric Bois and Rémy Beaudouin.

  • September 2014 – May 2015. Master 2 work placement at UCB Department Non-Clinical Development – Drug Metabolism and Pharmacokinetics. Subject: “Combiner allométrie et extrapolation in vitro – in vivo pour prédire la pharmacocinétique chez l’homme : Outils et cas d’études”.

  • Apr 2016 – Sep 2016. Specialist work placement at INERIS. Unit Models for Ecotoxicology and Toxicology. Subject: “Prédire l’exposition interne des enfants au plomb par modélisation pharmacocinétique basée sur la physiologie (PBPK)”.

  • Oct 2015 – Mar 2016. University hospital year internship at Robert Debré Hospital. Units of Chemotherapy preparation and neurology and metabolic diseases.

  • Jun – Aug 2015. . Research internship at Cochin Hospital. Laboratory of Pharmacology and Toxicology. Subject: “Pharmacocinétique du baclofène chez les patients intoxiqués”.

Education and training

• • Expected in 2020. AgroParisTech. Doctor of Philosophy. Subject: “Systemic mathematical modeling of reproductive and developmental toxicity of zebrafish”

  • 2018. Pharmacy Faculty Paris Descartes. Pharmacy Doctor. Subject: “Prédiction de la pharmacocinétique chez l’Homme à partir de données précliniques : Outils et cas d’études”.

  • 2016 – 2017. Pharmacy Faculty Paris Descartes. MSC in Pharmacokinetic modeling.