Internal Workshop on AOP/qAOP

Date of publication: 31th March, 2025

On Friday 21th of March 2025, we welcomed Dr. Dmitry Klokov, Head of the Laboratory of Radiotoxicology and Experimental Radiobiology (LRTOX) at ASNR (formerly IRSN). This morning was dedicated to the AOP and qAOP (quantitative Adverse Outcome Pathway) developed by our various laboratories.

1. Welcome

2. General introduction (5 minutes)

• • AOP/qAOP concept & generalities

  • Briefly how to develop an AOP

  • Fields of applications/development

  • List of AOP/guideline: AOP-Wiki

  • AOP/qAOP at Ineris

3. Developing an AOP from scratch in Radioprotection (10-15 minutes)

• Speaker: Dmitry KLOKOV

      Q&A (10-15 minutes)

5. Case Study 1: AOP - Radiation-induced acute myeloid leukemia (10-15 minutes)

• Speaker: Dmitry KLOKOV

Q&A (10-15 minutes)

Pause (15 min)

7. Case Study 2: qAOP - Aromatase Inhibition leading to reproductive dysfunction in fish (10 minutes)

• Speaker: Tu-Ky LY (+Rémy BEAUDOUIN)

• Content:

  • GinFiz and Ovotox project

  • Relevance for environmental risk assessment

    Q&A (10-15 minutes)

9. Case Study 3: AOP/qAOP at Ineris – mitochondrial toxicity and Parkinson’s Disease (15 minutes)

• Speaker: Cleo BODIN

10. Final general Q&A and general discussion