Poster on PFAAs TK in zebrafish embryos at the EURION 2022 Annual meeting

A poster presentation entilted "Interindividual variability in the hatching time impacts PFAAs toxicokinetics in Zebrafish embryos" was presented at the EURION 2022 Annual meeting (20th – 21st January 2022). EURION is the European Cluster to Improve Identification of Endocrine Disruptors (EDs), consists of eight H2020 research projects focusing on the development of new ED test methods targeting relevant endpoints that are not sufficiently covered by current regulatory tests (https://eurion-cluster.eu/). This work was carried out within the framework of the OBERON (https://oberon-4eu.com/).

Highlights:

• To further explore toxicity of PFAAs, several screening assays were performed using zebrafish embryo (ZFE) based experiments. During these experiments, ZFE undergo huge physiological changes (hatching, maturation of organs etc.) and their actual exposure is poorly accessible. A predictive model could estimate these concentrations and would enable toxicokinetic/toxicodynamic studies

• C. Vogs et al. observed that ZFE exposure to perfluoroalkylacids (PFAAs) is highly variable among these compounds and noticed an extensive interindividual variability in the hatching time. In addition, PFAAs revealed a discontinuity in their kinetics around hatching time suggesting chorion interference.

• In this context, we aimed at better characterizing the hatching process in order to improve the model predictions using the PFAAs dataset.