New article by Paul Quindroit on PBTK model linking multi-route exposures to pyrethroids

• • The model simulates the urinary metabolite levels from cumulative exposures.

  • 90% of model predictions fall into the 3-fold error interval.

  • Urinary concentrations are influenced mainly by the parent compounds metabolism.

  • Simulated exposures for France were in good agreement with biomonitoring data.

Estimating the cumulative human exposures to pyrethroids by combined multi-route PBPK models: Application to the French population.

Paul Quindroit, Rémy Beaudouin, Céline Brochot.

Toxicology Letters 312 (2019) 125–138