New article by Marc Codaccioni on pregnancy PBPK models

Date de publication : Sep 23, 2019 11:55:40 AM

We are pleased to let you know that the final version of the article "Placental transfer of xenobiotics in pregnancy physiologically-based pharmacokinetic models: Structure and data" is now available online !

Highlights

• We reviewed pregnancy PBPK models according to the modeling of placental transfers.

• Various placental sub-models were identified in the 50 original pPBPK models.

• Model simulations showed the influence of placental transfers on fetal exposures.

• We propose a new structure that integrates two placental vascularization steps.

• In silico and experimental methods providing quantitative transfer data are shown.