1. Complex: SARS-CoV Spike RBD in complex with neutralizing antibody m396

• CATH

• Resolution: 2.3 Å

• Species: Severe acute respiratory syndrome-related coronavirus 

2. Antigen: Spike (S) glycoprotein from Severe acute respiratory syndrome coronavirus 

• structure length (residues): 220

• mutations: No

• Uniprot

3. Antibody: Neutralizing monoclonal antibody m396

• Isotype/subclass: IgG1

• Structure: Fab only

3.1 Heavy chain 

• structure length (residues): 245

• mutations: No

• disulfide bridges: 22-96, 145-201

• CDR (residue numbering): 31-33, 50-52, 54, 55, 57, 59, 60, 99-103

3.2 Light chain

• structure length (residues): 213

• mutations: No

• disulfide bridges: 22-87, 135-194

• CDR (residue numbering): 26, 28-31, 90-93, 95, 96, 

RCSB PDB - 2DD8 - Crystal Structure of SARS-CoV Spike Receptor-Binding Domain Complexed with Neutralizing Antibody

SARS-CoV Spike RBD in complex with neutralizing antibody m396 (310K, 37°C, 100 ns) RMSD, SASA, RMSF, Rg, H-bonds

SARS-CoV Spike RBD in complex with neutralizing antibody m396 (311K, 38°C, 100 ns) RMSD, SASA, RMSF, Rg, H-bonds

SARS-CoV Spike RBD in complex with neutralizing antibody m396 (312K, 39°C, 100 ns) RMSD, SASA, RMSF, Rg, H-bonds

SARS-CoV Spike RBD in complex with neutralizing antibody m396 (313K, 40°C, 100 ns) RMSD, SASA, RMSF, Rg, H-bonds

1. Complex: SARS-CoV Spike RBD in complex with neutralizing antibody 80R 

• CATH

• Resolution: 2.3 Å

• Species: Severe acute respiratory syndrome-related coronavirus 

2. Antigen: Spike (S) glycoprotein from Severe acute respiratory syndrome coronavirus 

• structure length (residues): 203

• mutations: No

• Uniprot

3. Antibody: single-chain variable fragment mAb 80R

• Isotype/subclass: IgG1

• Structure: Fv

• structure length (residues): 247

• mutations: No

• disulfide bridges: 24-98, 157-222

• CDR (residue numbering): Heavy chain: 31-33, 50-53, 57, 59, 99-102, 105

• CDR (residue numbering): Light chain: 150, 161-164, 182-186, 195-199, 202-204, 206, 208, 223, 224, 226.

RCSB PDB - 2GHW - SARS-CoV Spike RBD in complex with neutralizing antibody 80R 

SARS-CoV Spike RBD in complex with neutralizing antibody 80R (310K, 37°C, 100 ns) RMSD, SASA, RMSF, Rg, H-bonds

SARS-CoV Spike RBD in complex with neutralizing antibody 80R (311K, 38°C, 100 ns) RMSD, SASA, RMSF, Rg, H-bonds

SARS-CoV Spike RBD in complex with neutralizing antibody 80R (312K, 39°C, 100 ns) RMSD, SASA, RMSF, Rg, H-bonds

SARS-CoV Spike RBD in complex with neutralizing antibody 80R (313K, 40°C, 100 ns) RMSD, SASA, RMSF, Rg, H-bonds