1. Complex: GM-CSF in complex with mouse 4D4 mAb

• CATH

• Resolution: 2.6 Å

• Species: H. sapiens, Mus musculus

2. Antigen: Granulocyte-macrophage colony-stimulating factor,  GM-CSF,  colony-stimulating factor 2, CSF2 

• structure length (residues): 127

• mutations: No

• Uniprot

3. Antibody: 4D4 mAb

• Structure: Fab only.

3.1 Heavy chain 

• structure length (residues): 225

• mutations: No

• disulfide bridges: 22-95, 142-198

• CDR (residue numbering): 28, 31-33, 50, 52, 56, 95-98

3.2 Light chain

• structure length (residues): 215

• mutations: No

• disulfide bridges: 24-89, 135-195

• CDR (residue numbering): 32, 91, 92, 94.

RCSB PDB - 6BFQ: The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies 

6BFQ, GM-CSF in complex  with autoantibody 4D4 (310K, 37°C, 100 ns)  >> RMSD, SASA, RMSF, Rg, H-bonds

6BFQ, GM-CSF in complex  with autoantibody 4D4 (311K, 38°C, 100 ns)  >> RMSD, SASA, RMSF, Rg, H-bonds

6BFQ, GM-CSF in complex  with autoantibody 4D4 (312K, 39°C, 100 ns)  >> RMSD, SASA, RMSF, Rg, H-bonds

6BFQ, GM-CSF in complex  with autoantibody 4D4 (313K, 40°C, 100 ns)  >> RMSD, SASA, RMSF, Rg, H-bonds