1. Complex: TSH receptor in complex with autoantibody K1-70 mAb 

• CATH

• Resolution: 1.9 Å

• Species: H. sapiens

2. Antigen: TSH receptor, Thyrotropin receptor, thyroid stimulating hormone receptor 

• structure length (residues): 239

• mutations: No.

• Uniprot

3. Antibody: autoantibody K1-70 

• Isotype/subclass: IgG1λ

• Structure: Fab only

3.1 Heavy chain 

• structure length (residues): 221

• mutations: No

• disulfide bridges: 22-96, 146-202

• CDR (residue numbering): 31, 54, 56, 58, 96, 101

3.2 Light chain

• structure length (residues): 214

• mutations: No

• disulfide bridges: 22-89, 138-197

• CDR (residue numbering): 27, 50, 54, 92, 94.

PDB - 2XWT: Crystal structure of TSH receptor in complex with human mAb autoantibody K1-70

TSH receptor in complex with autoantibody K1-70 (310K, 37°C, 400 ns): seed #1 >> RMSD, SASA, RMSF, Rg, H-bonds

TSH receptor in complex with autoantibody K1-70 (311K, 38°C, 400 ns): seed #1 >> RMSD, SASA, RMSF, Rg, H-bonds

TSH receptor in complex with autoantibody K1-70 (312K, 39°C, 400 ns): seed #1 >> RMSD, SASA, RMSF, Rg, H-bonds

TSH receptor in complex with autoantibody K1-70 (310K, 37°C, 400 ns): seed #2 >> RMSD, SASA, RMSF, Rg, H-bonds

TSH receptor in complex with autoantibody K1-70 (311K, 38°C, 400 ns): seed #2 >> RMSD, SASA, RMSF, Rg, H-bonds

TSH receptor in complex with autoantibody K1-70 (312K, 39°C, 400 ns): seed #2 >> RMSD, SASA, RMSF, Rg, H-bonds

TSH receptor in complex with autoantibody K1-70 (310K, 37°C, 400 ns): seed #3 >> RMSD, SASA, RMSF, Rg, H-bonds

TSH receptor in complex with autoantibody K1-70 (311K, 38°C, 400 ns): seed #3 >> RMSD, SASA, RMSF, Rg, H-bonds

TSH receptor in complex with autoantibody K1-70 (312K, 39°C, 400 ns): seed #3 >> RMSD, SASA, RMSF, Rg, H-bonds

TSH receptor in complex with autoantibody K1-70 (310K, 37°C, 200 ns): seed #4 >> RMSD, SASA, RMSF, Rg, H-bonds

TSH receptor in complex with autoantibody K1-70 (311K, 38°C, 200 ns): seed #4 >> RMSD, SASA, RMSF, Rg, H-bonds

TSH receptor in complex with autoantibody K1-70 (312K, 39°C, 200 ns): seed #4 >> RMSD, SASA, RMSF, Rg, H-bonds

TSH receptor in complex with autoantibody K1-70 (310K, 37°C, 200 ns): seed #5 >> RMSD, SASA, RMSF, Rg, H-bonds

TSH receptor in complex with autoantibody K1-70 (311K, 38°C, 200 ns): seed #5 >> RMSD, SASA, RMSF, Rg, H-bonds

TSH receptor in complex with autoantibody K1-70 (312K, 39°C, 200 ns): seed #5 >> RMSD, SASA, RMSF, Rg, H-bonds

Crystal structure of TSH receptor, (310K, 37°C, 100 ns): random seed #1

Crystal structure of TSH receptor, (311K, 38°C, 100 ns): random seed #1

Crystal structure of TSH receptor, (312K, 39°C, 100 ns): random seed #1

Crystal structure of TSH receptor, (313K, 40°C, 100 ns): random seed #1

Crystal structure of TSH receptor, (310K, 37°C, 100 ns): random seed #2

Crystal structure of TSH receptor, (311K, 38°C, 100 ns): random seed #2

Crystal structure of TSH receptor, (312K, 39°C, 100 ns): random seed #2

Crystal structure of TSH receptor, (313K, 40°C, 100 ns): random seed #2