1. Complex: IL-18 in complex with 125-2H mAb 

• CATH

• Resolution: 1.5 Å

• Species: H. sapiens, Mus musculus

2. Antigen: Interleukin-18, IL-18, interferon-gamma inducing factor 

• structure length (residues): 157

• mutations: 4

• Uniprot

3. Antibody: 125-2H mAb 

• Isotype/subclass: IgG1

• Structure: Fab only

3.1 Heavy chain 

• structure length (residues): 216

• mutations: No

• disulfide bridges: 22-96, 140-195

• CDR (residue numbering): 31-33, 50, 52, 53, 56

3.2 Light chain

• structure length (residues): 214

• mutations: No

• disulfide bridges: 23-88, 134-194

• CDR (residue numbering): 94, 101.

RCSB PDB - 2VXT: Human IL-18 in complex with mAb 125-2H 

IL -18 in complex with125-2H antibody (310K, 37°C, 100 ns) RMSD, SASA, RMSF, Rg, H-bonds

IL -18 in complex with125-2H antibody (311K, 38°C, 100 ns) RMSD, SASA, RMSF, Rg, H-bonds

IL -18 in complex with125-2H antibody (312K, 39°C, 100 ns) RMSD, SASA, RMSF, Rg, H-bonds

IL -18 in complex with125-2H antibody (313K, 40°C, 100 ns) RMSD, SASA, RMSF, Rg, H-bonds