1. Complex: CD38 in complex with SAR650984 mAb 

• CATH

• Resolution: 1.5 Å

• Species: H. sapiens, Mus musculus

2. Antigen: Cluster of differentiation 38, CD38, cyclic ADP ribose hydrolase 

• structure length (residues): 256

• mutations: 4

• Uniprot.

3. Antibody: SAR650984 mAb

• Isotype/subclass: IgG1

• Structure: Fab only

3.1 Heavy chain 

• structure length (residues): 234

• mutations: No

• disulfide bridges: 22-96, 147-203

• CDR (residue numbering): 31, 50, 55, 57, 92

3.2 Light chain

• structure length (residues): 214

• mutations: No

• disulfide bridges: 23-88, 134-194

RCSB PDB - 4CMH: Crystal structure of CD38 with a novel CD38-targeting antibody SAR650984 

CD-38 in complex with antibody SAR650984 (310K, 37°C, 100 ns)   RMSD, SASA, RMSF, Rg, H-bonds

CD-38 in complex with antibody SAR650984 (311K, 38°C, 100 ns)   RMSD, SASA, RMSF, Rg, H-bonds

CD-38 in complex with antibody SAR650984 (312K, 39°C, 100 ns)   RMSD, SASA, RMSF, Rg, H-bonds

CD-38 in complex with antibody SAR650984 (313K, 40°C, 100 ns)   RMSD, SASA, RMSF, Rg, H-bonds