1. Complex: CTLA-4 in complex with VH domain of 4003-1 mAb
Resolution: 2.3 Å
Species: H. sapiens
2. Antigen: Cytotoxic T-lymphocyte-associated protein 4, CTLA-4, cluster of differentiation 152, CD152
structure length (residues): 118
mutations: No
3. Antibody: 4003-1 mAb (Heavy chain only)
Isotype/subclass: IgG1
Structure: Fab only
structure length (residues): 120
mutations: No
disulfide bridges: 23-96
CDR (residue numbering): 15, 17, 42, 50, 66, 80
RCSB PDB - 7DV4: Crystal structure of anti-CTLA-4 VH domain in complex with human CTLA-4
Cytotoxic T-lymphocyte protein 4 in complex with 4003-1 antibody (310K, 37°C, 500 ns)
Cytotoxic T-lymphocyte protein 4 in complex with 4003-1 antibody (311K, 38°C, 500 ns)
Cytotoxic T-lymphocyte protein 4 in complex with 4003-1 antibody (312K, 39°C, 500 ns)
Cytotoxic T-lymphocyte protein 4 in complex with 4003-1 antibody (313K, 40°C, 500 ns)
1. Complex: CTLA-4 in complex with tremelimumab Fab
Resolution: 2 Å
Species: H. sapiens
2. Antigen: Cytotoxic T-lymphocyte-associated protein 4, CTLA-4, cluster of differentiation 152, CD152
sequence length (residues): 126
mutations: No
3. Antibody: tremelimumab
Isotype/subclass: IgG2
Structure: Fab only
3.1 Heavy chain
structure length (residues): 239
mutations: No
disulfide bridges: 22-96, 152-208
CDR (residue numbering): 52, 53, 57, 59, 101-108, 110
3.2 Light chain
structure length (residues): 214
mutations: No
disulfide bridges: 23-94, 50-68
CDR (residue numbering): 27, 28, 30, 32, 91-94
RCSB PDB - 5GGV: CTLA-4 in complex with tremelimumab Fab
1. Complex: CTLA-4 in complex with ipilimumab Fab
Resolution: 2.6 Å
Species: H. sapiens
2. Antigen: Cytotoxic T-lymphocyte-associated protein 4, CTLA-4, cluster of differentiation 152, CD152
structure length (residues): 118
mutations: No
3. Antibody: ipilimumab
Isotype/subclass: IgG1
Structure: Fab only
3.1 Heavy chain
structure length (residues): 225
mutations: No
disulfide bridges: 22-93, 49-67
CDR (residue numbering): 31, 33, 50, 52-42, 56, 57, 59, 99-103
3.2 Light chain
structure length (residues): 215
mutations: No
disulfide bridges: 23-89, 135-195
CDR (residue numbering): 32, 33, 50, 57, 92-95, 97
RCSB PDB - 6RP8: Crystal Structure of Ipilimumab Fab complexed with CTLA-4