1. Complex: DR5 in complex with Fab of Apomab 

• CATH

• Resolution: 3.2 Å

• Species: H. sapiens

2. Antigen: Death receptor 5, DR5, TRAIL receptor 2, tumor necrosis factor receptor superfamily member 10B, TNFRSF10B 

• structure length (residues): 111

• mutations: No.

• Uniprot

3. Antibody: Apomab 

• Isotype/subclass: IgG1

• Structure: Fab only.

3.1 Heavy chain 

• structure length (residues): 232

• mutations: No

• disulfide bridges: 21-86, 135-194

• CDR (residue numbering): 30, 31, 52-54, 57, 104, 107

3.2 Light chain

• structure length (residues): 213

• mutations: No

• disulfide bridges: 22-96, 148-204

• CDR (residue numbering): 26, 28-30.

RCSB PDB - 4OD2: Crystal structure of the Fab fragment of an anti-DR5 antibody bound to DR5 

Death Receptor 5 in complex with apomab (310K, 37°C, 100 ns) >>  RMSD, SASA, RMSF, Rg, H-bonds

Death Receptor 5 in complex with apomab (311K, 38°C, 100 ns) >>  RMSD, SASA, RMSF, Rg, H-bonds

Death Receptor 5 in complex with apomab (312K, 39°C, 100 ns) >>  RMSD, SASA, RMSF, Rg, H-bonds

Death Receptor 5 in complex with apomab (313K, 40°C, 100 ns) >>  RMSD, SASA, RMSF, Rg, H-bonds