1. Complex: Interleukin-1β in complex with canakinumab

• CATH

• Resolution: 2.2 Å

• Species: Mus musculus

2. Antigen: Interleukin-1β, IL-1β, interleukin-1 beta

• structure length (residues): 153

• mutations: No

• Uniprot

3. Antibody: canakinumab

• Isotype/subclass: IgG1/κ 

• Structure: Fab only.

3.1 Heavy chain 

• structure length (residues): 225

• mutations: No

• disulfide bridges: 22-96, 145-201.

• CDR (residue numbering): 19-23 27, 32, 34, 35, 37-39, 41, 64-66, 129

3.2 Light chain

• structure length (residues): 214

• mutations: No

• disulfide bridges: 23-88, 134-194

• CDR (residue numbering): 86-88.

RCSB PDB - 5BVP - Interleukin-1β in complex with canakinumab 

Interleukin-1β in complex with canakinumab (310K, 37°C, 100 ns) >> RMSD, SASA, RMSF, Rg, H-bonds

Interleukin-1β in complex with canakinumab (311K, 38°C, 100 ns) >> RMSD, SASA, RMSF, Rg, H-bonds

Interleukin-1β in complex with canakinumab (312K, 39°C, 100 ns) >> RMSD, SASA, RMSF, Rg, H-bonds

Interleukin-1β in complex with canakinumab (313K, 40°C, 100 ns) >> RMSD, SASA, RMSF, Rg, H-bonds