1. Complex: BAFF (CD257) in complex with belimumab 

• CATH

• Resolution: 2 Å

• Species: H. sapiens

2. Antigen: B-cell activating factor, BAFF, CD257, tumor necrosis factor ligand superfamily member 13B, TNFSF13B

• structure length (residues): 152

• mutations: No

• Uniprot

3. Antibody: belimumab 

• Isotype/subclass: IgG1λ 

• Structure: Fab only.

3.1 Heavy chain 

• structure length (residues): 235

• mutations: No

• disulfide bridges: 22-96, 150-206

• CDR (residue numbering): 31, 54, 55, 57, 101-104

3.2 Light chain

• structure length (residues): 214

• mutations: No

• disulfide bridges: 22-87, 136-195

• CDR (residue numbering): 28, 31, 50, 95

RCSB PDB - 5Y9J: BAFF in complex with belimumab 

BAFF in complex with belimumab (310K, 37°C, 100 ns), random seed #1 >> RMSD, SASA, RMSF, Rg, H-bonds

BAFF in complex with belimumab (311K, 38°C, 100 ns), random seed #1 >> RMSD, SASA, RMSF, Rg, H-bonds

BAFF in complex with belimumab (312K, 39°C, 100 ns), random seed #1 >> RMSD, SASA, RMSF, Rg, H-bonds

BAFF in complex with belimumab (313K, 40°C, 100 ns) , random seed #1>> RMSD, SASA, RMSF, Rg, H-bonds

BAFF in complex with belimumab (310K, 37°C, 100 ns), random seed #2 >> RMSD, SASA, RMSF, Rg, H-bonds

BAFF in complex with belimumab (311K, 38°C, 100 ns), random seed #2 >> RMSD, SASA, RMSF, Rg, H-bonds

BAFF in complex with belimumab (312K, 39°C, 100 ns), random seed #2 >> RMSD, SASA, RMSF, Rg, H-bonds

BAFF in complex with belimumab (313K, 40°C, 100 ns), random seed #2 >> RMSD, SASA, RMSF, Rg, H-bonds

BAFF in complex with belimumab (310K, 37°C, 100 ns), random seed #3 >> RMSD, SASA, RMSF, Rg, H-bonds

BAFF in complex with belimumab (311K, 38°C, 100 ns), random seed #3 >> RMSD, SASA, RMSF, Rg, H-bonds

BAFF in complex with belimumab (312K, 39°C, 100 ns), random seed #3 >> RMSD, SASA, RMSF, Rg, H-bonds

BAFF in complex with belimumab (313K, 40°C, 100 ns), random seed #3 >> RMSD, SASA, RMSF, Rg, H-bonds