1. Complex: IL-23 in complex with Fab of 7G10 mAb 

• CATH

• Resolution: 1.9 Å

• Species: H. sapiens

2. Antigen: Interleukin-23, IL-23

• structure length (residues): 178

• mutations: No

• Uniprot

3. Antibody: 7G10 mAb

• Isotype/subclass: IgG1

• Structure: Fab only

3.1 Heavy chain 

• structure length (residues): 223

• mutations: No

• disulfide bridges: 22-96, 142-198

• CDR (residue numbering): 35, 50, 54, 59, 101, 106.

3.2 Light chain

• structure length (residues): 214

• mutations: No

• disulfide bridges: 23-88, 134-194

• CDR (residue numbering): 32, 50, 92, 94, 96.

RCSB PDB - 3D85: Crystal structure of IL-23 in complex with neutralizing FAB 

IL-23 in complex with 7G10 antibody, random seed #1 (310K, 37°C, 100 ns) >> RMSD, SASA, RMSF, Rg, H-bonds

IL-23 in complex with 7G10 antibody, random seed #1 (311K, 38°C, 100 ns) >> RMSD, SASA, RMSF, Rg, H-bonds

IL-23 in complex with 7G10 antibody, random seed #1 (312K, 39°C, 100 ns) >> RMSD, SASA, RMSF, Rg, H-bonds

IL-23 in complex with 7G10 antibody, random seed #1 (313K, 40°C, 100 ns) >> RMSD, SASA, RMSF, Rg, H-bonds

IL-23 in complex with 7G10 antibody, random seed #2 (310K, 37°C, 100 ns) >> RMSD, SASA, RMSF, Rg, H-bonds

IL-23 in complex with 7G10 antibody, random seed #2 (311K, 38°C, 100 ns) >> RMSD, SASA, RMSF, Rg, H-bonds

IL-23 in complex with 7G10 antibody, random seed #2 (312K, 39°C, 100 ns) >> RMSD, SASA, RMSF, Rg, H-bonds

IL-23 in complex with 7G10 antibody, random seed #2 (313K, 40°C, 100 ns) >> RMSD, SASA, RMSF, Rg, H-bonds