1. Complex: ErbB2 (HER2) in complex with pertuzumab
Resolution: 3.2 Å
Species: H. sapiens
2. Antigen: Receptor tyrosine-protein kinase erbB-2, human epidermal growth factor receptor 2, HER2, cluster of differentiation 340
structure length (residues): 624
mutations: No
3. Antibody: pertuzumab
Isotype/subclass: IgG1
Structure: Fab only
3.1 Heavy chain
structure length (residues): 226
mutations: No
disulfide bridges: 22-96, 146-202
CDR (residue numbering): 30-32, 33, 52-53, 55, 58, 59, 96, 99, 244
3.2 Light chain
structure length (residues): 214
mutations: No
disulfide bridges: 23-88, 134-194
CDR (residue numbering): 49, 55, 94
RCSB PDB - 1S78: Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex
Erb2 (HER-2) in complex with pertuzumab (310K, 37°C, 100 ns) RMSD, SASA, RMSF, Rg, H-bonds
Erb2 (HER-2) in complex with pertuzumab (311K, 38°C, 100 ns) RMSD, SASA, RMSF, Rg, H-bonds
Erb2 (HER-2) in complex with pertuzumab (312K, 39°C, 100 ns) RMSD, SASA, RMSF, Rg, H-bonds
Erb2 (HER-2) in complex with pertuzumab (313K, 40°C, 100 ns) RMSD, SASA, RMSF, Rg, H-bonds
1. Complex: ErbB2 (HER2) in complex with Fab of cetuximab/Erbitux
Resolution: 3.2 Å
Species: H. sapiens
2. Antigen: Receptor tyrosine-protein kinase erbB-2, human epidermal growth factor receptor 2, HER2, cluster of differentiation 340
structure length (residues): 624
mutations: No
3. Antibody: cetuximab
Isotype/subclass: IgG1
Structure: Fab only
3.1 Heavy chain
structure length (residues): 221
mutations: No
disulfide bridges: 22-95, 146-202
CDR (residue numbering): 52, 54, 56, 58, 101-104
3.2 Light chain
structure length (residues): 213
mutations: No
disulfide bridges: 23-88, 134-194
CDR (residue numbering): 27, 50, 94
RCSB PDB - 1YY9: Extracellular domain of ERB2 in complex with Fab of cetuximab/Erbitux/IMC-C225