1. Complex: ErbB2 (HER2) in complex with pertuzumab 

• CATH

• Resolution: 3.2 Å

• Species: H. sapiens

2. Antigen: Receptor tyrosine-protein kinase erbB-2, human epidermal growth factor receptor 2,  HER2, cluster of differentiation 340  

• structure length (residues): 624

• mutations: No

• Uniprot

3. Antibody: pertuzumab 

• Isotype/subclass: IgG1

• Structure: Fab only

3.1 Heavy chain 

• structure length (residues): 226

• mutations: No

• disulfide bridges: 22-96, 146-202

• CDR (residue numbering): 30-32, 33, 52-53, 55, 58, 59, 96, 99, 244

3.2 Light chain

• structure length (residues): 214

• mutations: No

• disulfide bridges: 23-88, 134-194

• CDR (residue numbering): 49, 55, 94

RCSB PDB - 1S78: Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex 

Erb2 (HER-2) in complex with pertuzumab (310K, 37°C, 100 ns)

Erb2 (HER-2) in complex with pertuzumab (311K, 38°C, 100 ns)

Erb2 (HER-2) in complex with pertuzumab (312K, 39°C, 100 ns)

Erb2 (HER-2) in complex with pertuzumab (313K, 40°C, 100 ns)