1. Complex: PD-L1 in complex with avelumab 

• CATH

• Resolution: 3.2 Å.

• Species: H. sapiens.

2. Antigen: Programmed death-ligand 1, PD-L1, cluster of differentiation 274, CD274, B7 homolog 1, B7-H1 

• structure length (residues): 221

• mutations: No

• Uniprot

3. Antibody: avelumab 

• Isotype/subclass: IgG1

• Structure: Fab only.

3.1 Heavy chain 

• structure length (residues): 120

• mutations: No

• disulfide bridges: 22-96

• CDR (residue numbering): 27, 28, 31, 33, 52, 54, 55, 57, 59, 101, 102-106

3.2 Light chain

• structure length (residues): 110

• mutations: No

• disulfide bridges: 22-90

• CDR (residue numbering): 32, 34, 93, 95, 97, 99.

RCSB PDB - 5GRJ: Crystal structure of human PD-L1 in complex with monoclonal antibody avelumab 

PD-L1 in complex with antibody avelumab (298K, 25°C, 100 ns)  >> RMSD, SASA, RMSF, Rg, H-bonds

PD-L1 in complex with antibody avelumab (310K, 37°C, 100 ns)  >> RMSD, SASA, RMSF, Rg, H-bonds

PD-L1 in complex with antibody avelumab (311K, 38°C, 100 ns) >> RMSD, SASA, RMSF, Rg, H-bonds

PD-L1 in complex with antibody avelumab (312K, 39°C, 100 ns) >> RMSD, SASA, RMSF, Rg, H-bonds

PD-L1 in complex with antibody avelumab (313K, 40°C, 100 ns) >> RMSD, SASA, RMSF, Rg, H-bonds