1. Complex: IL-12 in complex with Fab of ustekinumab 

• CATH

• Resolution: 3 Å

• Species: H. sapiens

2. Antigen: Interleukin-12, IL-12

• structure length (residues): 197

• mutations: No

• Uniprot

3. Antibody: ustekinumab 

• Isotype/subclass: IgG1k

• Structure: Fab only

3.1 Heavy chain 

• structure length (residues): 226

• mutations: No

• disulfide bridges: 22-96, 146-202

• CDR (residue numbering): 2, 27, 28, 31-33, 56, 58, 94, 96-98

3.2 Light chain

• structure length (residues): 214

• mutations: No

• disulfide bridges: 23-88, 134-194

• CDR (residue numbering): 30, 32, 49, 91-94.

RCSB PDB - 3HMX: Crystal structure of ustekinumab FAB/IL-12 complex 

Ustekinumab in complex with IL-12 (310K, 37°C, 100 ns), random seed #1 >> RMSD, SASA, RMSF, Rg, H-bonds

Ustekinumab in complex with IL-12 (311K, 38°C, 100 ns), random seed #1 >> RMSD, SASA, RMSF, Rg, H-bonds

Ustekinumab in complex with IL-12 (312K, 39°C, 100 ns), random seed #1 >> RMSD, SASA, RMSF, Rg, H-bonds

Ustekinumab in complex with IL-12 (313K, 40°C, 100 ns), random seed #1 >> RMSD, SASA, RMSF, Rg, H-bonds

Ustekinumab in complex with IL-12 (310K, 37°C, 100 ns), random seed #2 >> RMSD, SASA, RMSF, Rg, H-bonds

Ustekinumab in complex with IL-12 (311K, 38°C, 100 ns), random seed #2 >> RMSD, SASA, RMSF, Rg, H-bonds

Ustekinumab in complex with IL-12 (312K, 39°C, 100 ns), random seed #2>> RMSD, SASA, RMSF, Rg, H-bonds

Ustekinumab in complex with IL-12 (313K, 40°C, 100 ns), random seed #2 >> RMSD, SASA, RMSF, Rg, H-bonds