1. Complex: Autoantibody ACPA E4 in complex with CII-C-48-CIT peptide 

• CATH

• Resolution: 2.6 Å

• Species: H. sapiens

2. Antigen: Type II collagen citrullinated peptide, CII-C-48-CIT, 1CEAGEPGEXGLKGHRGCA18 

• structure length (residues): 18

• mutations: No

• Uniprot

3. Antibody: Autoantibody ACPA E4

• Class: IgG

• Structure: Fab only

3.1 Heavy chain 

• structure length (residues): 220

• mutations: No

• disulfide bridges: 22-96, 147-202

• CDR (residue numbering): 34, 48, 51, 53, 59, 99

3.2 Light chain

• structure length (residues): 216

• mutations: No

• disulfide bridges: 22-89, 138-197

• CDR (residue numbering): 31, 32, 52, 67, 92, 94, 99

RCSB PDB - 5OCY: Crystal structure of ACPA E4 in complex with CII-C-48-CIT

ACPA E4 autoantibody in complex with CII-C-48-CIT peptide (310K, 37°C, 100 ns)

ACPA E4 autoantibody in complex with CII-C-48-CIT peptide (311K, 38°C, 100 ns)

ACPA E4 autoantibody in complex with CII-C-48-CIT peptide (312K, 39°C, 100 ns)

ACPA E4 autoantibody in complex with CII-C-48-CIT peptide (313K, 40°C, 100 ns)