1. Complex: IL-17A in complex with HB0017 mAb 

• CATH

• Resolution: 2.8 Å

• Species: H. sapiens

2. Antigen: Interleukin-17A, IL-17A, CTLA-8 

• structure length (residues): 151

• mutations: No

• Uniprot

3. Antibody: HB0017 mAb

• Isotype/subclass: IgG1

• Structure: Fab only.

3.1 Heavy chain 

• structure length (residues): 217

• mutations: No

• disulfide bridges: 90-140, 95-142

• CDR (residue numbering): 31, 101, 103, 124

3.2 Light chain

• structure length (residues): 219

• mutations: No

• disulfide bridges: 23-93, 139-199

• CDR (residue numbering): 31-34, 37, 54, 55

RCSB PDB - 7WKX: IL-17A in complex with the humanized antibody HB0017 

IL-17a in complex with the humanized antibody HB0017 (310K, 37°C, 100 ns) RMSD, SASA, RMSF, Rg, H-bonds

IL-17a in complex with the humanized antibody HB0017 (311K, 38°C, 100 ns) RMSD, SASA, RMSF, Rg, H-bonds

IL-17a in complex with the humanized antibody HB0017 (312K, 39°C, 100 ns) RMSD, SASA, RMSF, Rg, H-bonds

IL-17a in complex with the humanized antibody HB0017 (313K, 40°C, 100 ns)    RMSD, SASA, RMSF, Rg, H-bonds