1. Complex: TNFα in complex with Fab of Infliximab

• CATH

• Resolution: 2.6 Å

• Species: H. sapiens

2. Antigen: Tumor necrosis factor alpha,TNFalpha, TNF-α, cachexin

• structure length (residues): 157

• mutations: No

• Uniprot

3. Antibody: Infliximab (chimeric)

• Isotype/subclass: IgG1

• Structure: Fab only

3.1 Heavy chain 

• structure length (residues): 226

• mutations: No

• disulfide bridges: 22-98, 147-203

• CDR (residue numbering): 31, 33, 50, 52, 53, 55, 56, 102, 103, 105

3.2 Light chain

• structure length (residues): 214

• mutations: No

• disulfide bridges: 23-88, 134-194

• CDR (residue numbering): 50, 92-94

RCSB PDB - 4G3Y: Crystal structure of TNFalpha in complex with Infliximab Fab fragment 

TNF-alpha in complex with Infliximab Fab fragment (310K, 37°C, 200 ns) - random seed #1

TNF-alpha in complex with Infliximab Fab fragment (311K, 38°C, 200 ns) - random seed #1

TNF-alpha in complex with Infliximab Fab fragment (312K, 39°C, 200 ns) - random seed #1

TNF-alpha in complex with Infliximab Fab fragment (310K, 37°C, 200 ns) - random seed #2

TNF-alpha in complex with Infliximab Fab fragment (311K, 38°C, 200 ns) - random seed #2

TNF-alpha in complex with Infliximab Fab fragment (312K, 39°C, 200 ns) - random seed #2

TNF-alpha in complex with Infliximab Fab fragment (310K, 37°C, 200 ns) - random seed #3

TNF-alpha in complex with Infliximab Fab fragment (311K, 38°C, 200 ns) - random seed #3 

TNF-alpha in complex with Infliximab Fab fragment (312K, 39°C, 200 ns) - random seed #3 

TNF-alpha in complex with Infliximab Fab fragment (310K, 37°C, 200 ns) - random seed #4

TNF-alpha in complex with Infliximab Fab fragment (311K, 38°C, 200 ns) - random seed #4

TNF-alpha in complex with Infliximab Fab fragment (312K, 39°C, 200 ns) - random seed #4

TNF-alpha in complex with Infliximab Fab fragment (310K, 37°C, 200 ns) - random seed #5

TNF-alpha in complex with Infliximab Fab fragment (311K, 38°C, 200 ns) - random seed #5

TNF-alpha in complex with Infliximab Fab fragment (312K, 39°C, 200 ns) - random seed #5