自分史

４月 西野氏が宮崎大学独立准教授に。とてもいいところ。UCSDみたい。ペットの再生医療を。

寺井氏、豊田氏と共に独立していく人が増える。とてもいいことだけど、寂しくもある。

３月 世古氏が国立リハビリテーションセンターへ移動。国家公務員に。

Kami D, Takeda S, Makino H, Toyoda M, Itakura Y, Gojo S, Kyo S, Umezawa A, Watanabe M.: Efficient transfection method using deacylated polyethylenimine-coated magnetic nanoparticles.

J Artif Organs. 2011

Sato B, Katagiri YU, Miyado K, Okino N, Ito M, Akutsu H, Okita H, Umezawa A, Fujimoto J, Toshimori K, Kiyokawa N.: Lipid rafts enriched in monosialylGb5Cer carrying the stage-specific embryonic antigen-4 epitope are involved in development of mouse preimplantation embryos at cleavage stage. BMC Dev Biol. 11:22, 2011.

Tateno H, Toyoda M, Saito S, Onuma Y, Ito Y, Hiemori K, Fukumura M, Nakasu A, Nakanishi M, Ohnuma K, Akutsu H, Umezawa A, Horimoto K, Hirabayashi J, Asashima M.: Glycome diagnosis of human induced pluripotent stem cells using lectin microarray. J Biol Chem. 2011

Suzuki K, Sun R, Origuchi M, Kanehira M, Takahata T, Itoh J, Umezawa A, Kijima H, Fukuda S, Saijo Y.: Mesenchymal Stromal Cells Promote Tumor Growth Through the Enhancement of Neovascularization. Mol Med. 2011 doi: 10.2119/molmed.2010.00157.

Hasebe Y, Hasegawa S, Hashimoto N, Toyoda M, Matsumoto K, Umezawa A, Yagami A, Matsunaga K, Mizutani H, Nakata S, Akamatsu H.: Analysis of cell characterization using cell surface markers in the dermis. J Dermatol Sci. 62(2):98-106, 2011.

Higuchi A, Ling QD, Ko YA, Chang Y, Umezawa A.: Biomaterials for the feeder-free culture of human embryonic stem cells and induced pluripotent stem cells. Chem Rev. 111:3021-3035, 2011.

Mimura S, Kimura N, Hirata M, Tateyama D, Hayashida M, Umezawa A, Kohara A, Nikawa H, Okamoto T, Furue MK.: Growth factor-defined culture medium for human mesenchymal stem cells. Int J Dev Biol. 2011.

Nishi M, Akutsu H, Masui S, Kondo A, Nagashima Y, Kimura H, Perrem K, Shigeri Y, Toyoda M, Okayama A, Hirano H, Umezawa A, Yamamoto N, Lee SW, Ryo A.: A distinct role for Pin1 in the induction and maintenance of pluripotency. J Biol Chem. 2011 Apr 1;286(13):11593-11603, 2011.

Sato T, Iso Y, Uyama T, Kawachi K, Wakabayashi K, Omori Y, Soda T, Shoji M, Koba S, Yokoyama S, Fukuda N, Saito S, Katagiri T, Kobayashi Y, Takeyama Y, Umezawa A, Suzuki H.: Coronary vein infusion of multipotent stromal cells from bone marrow preserves cardiac function in swine ischemic cardiomyopathy via enhanced neovascularization. Lab Invest. 91(4):553-564, 2011.

Yazawa T, Kawabe S, Inaoka Y, Okada R, Mizutani T, Imamichi Y, Ju Y, Yamazaki Y, Usami Y, Kuribayashi M, Umezawa A, Miyamoto K.: Differentiation of mesenchymal stem cells and embryonic stem cells into steroidogenic cells using steroidogenic factor-1 and liver receptor homolog-1. Mol Cell Endocrinol. 336:127-132, 2011.

Inamura M, Kawabata K, Takayama K, Tashiro K, Sakurai F, Katayama K, Toyoda M, Akutsu H, Miyagawa Y, Okita H, Kiyokawa N, Umezawa A, Hayakawa T, Furue MK, Mizuguchi H.: Efficient generation of hepatoblasts from human ES cells and iPS cells by transient overexpression of homeobox gene HEX.

Umezawa A, Gorham JD: Dueling models in head and neck tumor formation. Lab Invest. 90(11):1546, 2010.

Nishino K, Toyoda M, Yamazaki-Inoue M, Makino H, Fukawatase Y, Chikazawa E, Takahashi Y, Miyagawa Y, Okita H, Kiyokawa N, Akutsu H, Umezawa A.: Defining hypo-methylated regions of stem cell-specific promoters in human iPS cells derived from extra-embryonic amnions and lung fibroblasts. PLoS One, 5(9):e13017, 2010.

Fujino T, Nomura K, Ishikawa Y, Makino H, Umezawa A, Aburatani H, Nagasaki K, Nakamura T., Function of EWS-POU5F1 in sarcomagenesis and tumor cell maintenance. Am J Pathol., 176(4):1973, 2010

Ikegami Y, Miyoshi S(corresponding author), Nishiyama N, Hida N, Okamoto K, Miyado K, Segawa K, Ogawa S, Umezawa A. Serum-independent cardiomyogenic transdifferentiation in human endometrium-derived mesenchymal cells. Artificial Organs 2009, in press.

Yazawa, T., Inaoka, Y., Okada, R., Mizutani, T., Yamazaki, Y., Usami, Y., Kuribayashi, M., Orisaka, M., Umezawa, A., Miyamoto, K.: Peroxisome proliferator-activated receptor-gamma coactivator-1 alpha regulates progesterone production in ovarian granulosa cells with steroidogenic factor-1 and liver receptor homolog-1. Mol. Endocrinol. 24(3), 485-496; 2010.

Yazawa, T., Inaoka, Y., Mizutani, T., Kuribayashi, M., Umezawa, A., Miyamoto, K. : Liver Receptor Homolog-1 regulates the transcription of steroidogenic enzymes and induces the differentiation of mesenchymal stem cells into steroidogenic cells. Endocrinology 150(8), 3885-3893, 2009.

Kawamichi Y, Cui CH, Toyoda M, Makino H, Horie A, Takahashi Y, Matsumoto K, Saito H, Ohta H, Saito K, Umezawa A. Cells of Extraembryonic Mesodermal Origin Confer Human Dystrophin in the Mdx Model of Duchenne Muscular Dystrophy. J Cell Physiol (in press)

Haraguchi Y, Sekine W, Shimizu T, Yamato M, Miyoshi S, Umezawa A, Okano T. Development of a new assay system for evaluating the permeability of various substances through 3-dimensional tissue. Tissue Eng Part C Methods. 2009, doi:10.1089/ten.TEC.2009.0459. (in press)

Yamada M, Hamatani T, Akutsu H, Chikazawa N, Kuji N, Yoshimura Y, Umezawa A. Involvement of a novel preimplantation-specific gene encoding the high mobility group box protein Hmgpi in early embryonic development. Hum Mol Genet. 19(3):480-493, 2010.

Nagata S, Toyoda M, Yamaguchi S, Hirano K, Makino H, Nishino K, Miyagawa Y, Okita H, Kiyokawa N, Nakagawa M, Yamanaka S, Akutsu H, Umezawa A, Tada T. Efficient reprogramming of human and mouse primary extra-embryonic cells to pluripotent stem cells. Genes Cells. 14(12):1395-1404, 2009.

Takahashi H, Toyoda M, Birumachi J, Horie A, Uyama T, Miyado K, Matsumoto K, Saito H, Umezawa A. Shortening of human cell life span by induction of p16ink4a through the platelet-derived growth factor receptor beta. J Cell Physiol. 221(2):335-342, 2009.

Makino H, Toyoda M, Matsumoto K, Saito H, Nishino K, Fukawatase Y, Machida M, Akutsu H, Uyama T, Miyagawa Y, Okita H, Kiyokawa N, Fujino T, Ishikawa Y, Nakamura T, Umezawa A. Mesenchymal to embryonic incomplete transition of human cells by chimeric OCT4/3 (POU5F1) with physiological co-activator EWS. Exp Cell Res. 315(16):2727-2740, 2009.

Akutsu H, Miura T, Machida M, Birumachi JI, Hamada A, Yamada M, Sullivan S, Miyado K, Umezawa A. Maintenance of pluripotency and self-renewal ability of mouse embryonic stem cells in the absence of tetraspanin CD9. Differentiation. 78(2-3):137-142, 2009.

Yazawa, T, Inanoka Y, Mizutani T, Kuribayashi M, Umezawa A, Miyamoto K. Liver receptor homolog-1 regulates the transcription of steroidogenic enzymes and induces the differentiation of mesenchymal stem cells into steroidogenic cells. Endocrinology. 150(8):3885-3893, 2009.

Katsube K, Ichikawa S, Katsuki Y, Kihara T, Terai M, Lau LF, Tamamura Y, Takeda S, Umezawa A, Sakamoto K, Yamaguchi A. CCN3 and bone marrow cells. J Cell Commun Signal. 3(2):135-145, 2009.

Segawa Y, Muneta T, Makino H, Nimura A, Mochizuki T, Ju YJ, Ezura Y, Umezawa A, Sekiya I. Mesenchymal stem cells derived from synovium, meniscus, anterior cruciate ligament, and articular chondrocytes share similar gene expression profiles. J Orthop Res. 27(4):435-441, 2009.

Miyagawa Y, Okita H, Itagaki M, Toyoda M, Katagiri YU, Fujimoto J, Hata J, Umezawa A, Kiyokawa N. EWS/ETS regulates the expression of the Dickkopf family in Ewing family tumor cells. PLoS One. 4(2):e4634, 2009.

Hamatani T, Yamada M, Akutsu H, Kuji N, Mochimaru Y, Takano M, Toyoda M, Miyado K, Umezawa A, Yoshimura Y. What can we learn from gene expression profiling of mouse oocytes? Reproduction. 135(5):581-592, 2008.

Hida N, Nishiyama N, Miyoshi S, Kira S, Segawa K, Uyama T, Mori T, Miyado K, Ikegami Y, Cui C, Kiyono T, Kyo S, Shimizu T, Okano T, Sakamoto M, Ogawa S, Umezawa A. Novel cardiac precursor-like cells from human menstrual blood-derived mesenchymal cells. Stem Cells. 26(7):1695-1704; 2008

Inaoka Y, Yazawa T, Mizutani T, Kokame K, Kangawa K, Uesaka M, Umezawa A, Miyamoto K. Regulation of P450 oxidoreductase by gonadotropins in rat ovary and its effect on estrogen production. Reprod Biol Endocrinol.6(1):62;2008

Inoue S, Imamura M, Umezawa A, Tabata Y. Attachment, proliferation and adipogenic differentiation of adipo-stromal cells on self-assembled monolayers of different chemical compositions. J Biomater Sci Polym Ed.19(7):893-914;2008

Ishii K, Yoshida Y, Akechi Y, Sakabe T, Nishio R, Ikeda R, Terabayashi K, Matsumi Y, Gonda K, Okamoto H, Takubo K, Tajima F, Tsuchiya H, Hoshikawa Y, Kurimasa A, Umezawa A, Shiota G. Hepatic differentiation of human bone marrow-derived mesenchymal stem cells by tetracycline-regulated hepatocyte nuclear factor 3beta. Hepatology. 48(2):597-606;2008

Kami D, Shiojima I, Makino H, Matsumoto K, Takahashi Y, Ishii R, Naito AT, Toyoda M, Saito H, Watanabe M, Komuro I, Umezawa A. Gremlin enhances the determined path to cardiomyogenesis. PLoS ONE. 3(6):e2407;2008

Katsuki Y, Sakamoto K, Minamizato T, Makino H, Umezawa A, Ikeda MA, Perbal B, Amagasa T, Yamaguchi A, Katsube K. Inhibitory effect of CT domain of CCN3/NOV on proliferation and differentiation of osteogenic mesenchymal stem cells, Kusa-A1. Biochem Biophys Res Commun. 368(3):808-814 ;2008

Kawakita A, Sato K, Makino H, Ikegami H, Takayama S, Toyama Y, Umezawa A. Nicotine acts on growth plate chondrocytes to delay skeletal growth through the alpha7 neuronal nicotinic acetylcholine receptor. PLoS ONE. 3(12):e3945;2008

Miyado K, Yoshida K, Yamagata K, Sakakibara K, Okabe M, Wang X, Miyamoto K, Akutsu H, Kondo T, Takahashi Y, Ban T, Ito C, Toshimori K, Nakamura A, Ito M, Miyado M, Mekada E, Umezawa A. The fusing ability of sperm is bestowed by CD9-containing vesicles released from eggs in mice. Proc Natl Acad Sci U S A. 105(35):12921-12926;2008

Miyagawa Y, Okita H, Nakaijima H, Horiuchi Y, Sato B, Taguchi T, Toyoda M, Katagiri YU, Fujimoto J, Hata J, Umezawa A, Kiyokawa N. Inducible expression of chimeric EWS/ETS proteins confers Ewing's family tumor-like phenotypes to human mesenchymal progenitor cells. Mol Cell Biol.28(7):2125-2137;2008

Mohri Y, Kato S, Umezawa A, Okuyama R, Nishimori K. Impaired hair placode formation with reduced expression of hair follicle-related genes in mice lacking Lgr4. Dev Dyn. 237(8):2235-2242 ;2008

Morito T, Muneta T, Hara K, Ju YJ, Mochizuki T, Makino H, Umezawa A, Sekiya I. Synovial fluid-derived mesenchymal stem cells increase after intra-articular ligament injury in humans. Rheumatology (Oxford). 47(8):1137-1143; 2008

Nimura A, Muneta T, Koga H, Mochizuki T, Suzuki K, Makino H, Umezawa A, Sekiya I. Increased proliferation of human synovial mesenchymal stem cells with autologous human serum: comparisons with bone marrow mesenchymal stem cells and with fetal bovine serum. Arthritis Rheum. 58(2):501-510;2008

Oikawa K, Yoshida K, Takanashi M, Tanabe H, Kiyuna T, Ogura M, Saito A, Umezawa A, Kuroda M. Dioxin interferes in chromosomal positioning through the aryl hydrocarbon receptor. Biochem Biophys Res Commun. 374(2):361-364;2008

Segawa Y, Muneta T, Makino H, Nimura A, Mochizuki T, Ju YJ, Ezura Y, Umezawa A, Sekiya I. Mesenchymal stem cells derived from synovium, meniscus, anterior cruciate ligament, and articular chondrocytes share similar gene expression profiles. J Orthop Res. 2008.

Seko Y, Azuma N, Takahashi Y, Makino H, Morito T, Muneta T, Matsumoto K, Saito H, Sekiya I, Umezawa A. Human sclera maintains common characteristics with cartilage throughout evolution. PLoS ONE. 3(11):e3709;2008

Shiraki N, Yoshida T, Araki K, Umezawa A, Higuchi Y, Goto H, Kume K, Kume S. Guided differentiation of embryonic stem cells into Pdx1-expressing regional-specific definitive endoderm. Stem Cells. 26(4):874-885;2008

Sullivan S, Ichida JK, Umezawa A, Akutsu H. Elucidating nuclear reprogramming mechanisms: taking a synergistic approach. Reprod Biomed Online. 16(1):41-50;2008

Tanigawa M, Miyamoto K, Kobayashi S, Sato M, Akutsu H, Okabe M, Mekada E, Sakakibara K, Miyado M, Umezawa A, Miyado K. Possible involvement of CD81 in acrosome reaction of sperm in mice. Mol Reprod Dev.75(1):150-155;2008

Tokunaga A, Oya T, Ishii Y, Motomura H, Nakamura C, Ishizawa S, Fujimori T, Nabeshima Y, Umezawa A, Kanamori M, Kimura T, Sasahara M. PDGF receptor beta is a potent regulator of mesenchymal stromal cell function. J Bone Miner Res.23(9):1519-1528;2008

Yazawa T, Uesaka M, Inaoka Y, Mizutani T, Sekiguchi T, Kajitani T, Kitano T, Umezawa A, Miyamoto K. Cyp11b1 is induced in the murine gonad by luteinizing hormone/human chorionic gonadotropin and involved in the production of 11-ketotestosterone, a major fish androgen: conservation and evolution of the androgen metabolic pathway. Endocrinology.149(4):1786-1792; 2008

Zhu W, Shiojima I, Ito Y, Li Z, Ikeda H, Yoshida M, Naito AT, Nishi J, Ueno H, Umezawa A, Minamino T, Nagai T, Kikuchi A, Asashima M, Komuro I. IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. Nature.454(7202):345-349;2008

Okamoto, K., Miyoshi, S., Toyoda, M., Hida, N., Ikegami, Y., Makino, H., Nishiyama, N., Tsuji, H., Cui, C.H., Segawa, K., Uyama, T., Kami, D., Miyado, K., Asada, H., Matsumoto, K., Saito, H., Yoshimura, Y., Ogawa, S., Aeba, R., Yozu, R., Umezawa, A: 'Working' cardimyocytes exhibiting plateau action potentials from human placenta-derived extraembryonic mesodermal cells. Exp. Cell Res., 313: 2550-2563, 2007. AU is a corresponding author.

Cui CH, Uyama T, Miyado K, Terai M, Kyo S, Kiyono T, Umezawa A.: Menstrual Blood-derived Cells Confer Human Dystrophin Expression in the Murine Model of Duchenne Muscular Dystrophy via Cell Fusion and Myogenic Transdifferentiation. Mol Biol Cell. 18(5):1586-1594, 2007. AU is a corresponding author.

Sato, B., Katagiri, Y.U., Miyado, K., Akutsu, H., Miyagawa, Y., Horiuchi, Y., Nakajima, H., Okita, H., Umezawa, A., Hata, J-i., Fujimoto, J., Toshimori, K., Kiyokawa, N.: Preferential localization of SSEA-4 in interfaces between blastomeres of mouse preimplantaion embryos. Biochem. Biophys. Res. Co., in press.

Nimura, A., Muneta, T., Koga, H., Mochizuki, T., Suzuki, K., Makino, H., Umezawa, A., Sekiya, I.: Human synovial mesenchymal stem cells increase with human autologous serum; A comparison to fetal bovine seruma snd to bone marrow cells. Arthritis and Rheumatism, in press.

Kato, S., Mohri, K., Matsuo, T., Ogawa, E., Umezawa, A., Okuyama, R., Nishimori, K.: Eye-open at birth phenotype with reduced keratinocyte motility in LGR4 null mice. FEBS Letter, 581: 4685-4960, 2007.

Yoshida Y, Shimomura T, Sakabe T, Ishii K, Gonda K, Matsuoka S, Watanabe Y, Takubo K, Tsuchiya H, Hoshikawa Y, Kurimasa A, Hisatome I, Uyama T, Terai M, Umezawa, A., Shiota G. A role of Wnt/{beta}-catenin signals in hepatic fate specification of human umbilical cord blood-derived mesenchymal stem cells. Am J Physiol Gastrointest Liver Physiol. In press.

Toyoda, M., Hamatani, T., Matsumoto, K., Saito, H., Umezawa, A.: Get a cell dead to rights in reproduction... Current Medicinal Chemistry, in press. AU is a corresponding author.

Toyoda, M., Takahashi, H., Umezawa, A: Ways for a mesenchymal stem cell to live on its own: maintaining an undifferentiated state ex vivo. Int J Hematol. 86:1-4, 2007. AU is a corresponding author.

Shimomura, T., Yoshida, Y., Sakabe, T., Ishii, K., Gonda, K., Murai, R., Takubo, K., Tuchiya, H., Hoshikawa, Y., Kurimasa, A., Hisatome, I., Uyama, T., Umezawa, A., Shiota, G: Hepatic differentiation of human bone marrow-derived UE7T-13 cells: Effects of cytokines and CCN family gene expression. Hepatic Res, in press.

Takeuchi M, Takeuchi K, Kohara A, Satoh M, Shioda S, Ozawa Y, Ohtani A, Morita K, Hirano T, Terai M, Umezawa A, Mizusawa H.: Chromosomal instability in human mesenchymal stem cells immortalized with human papilloma virus E6, E7, and hTERT genes. In Vitro Cell Dev Biol Anim. 2007

Hashii, N., Kawasaki, N., Nakajima, Y., Toyoda, M., Katagiri, Y., Itoh, S., Harazono, A., Umezawa, A., Yamaguchi T.: Study on the quality control of cell therapy products Determination of N-glycolylneuraminic acid incorporated into human cells by nano-flow liquid chromatography/Fourier transformation ion cyclotron mass spectrometry. J Chromatogr A. 2007

Nishiyama N, Miyoshi S, Hida N Miss, Uyama T, Okamoto K, Ikegami Y, Miyado K, Segawa K, Terai M, Sakamoto M, Ogawa S, Umezawa A.: The Significant Cardiomyogenic Potential of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Vitro. Stem Cells. 25(8):2017-2024, 2007

Kondo S, Shukunami C, Morioka Y, Matsumoto N, Takahashi R, Oh J, Atsumi T, Umezawa A, Kudo A, Kitayama H, Hiraki Y, Noda M.: Dual effects of the membrane-anchored MMP regulator RECK on chondrogenic differentiation of ATDC5 cells. J Cell Sci. 120(Pt 5):849-857, 2007.

Tanigawa M, Miyamoto K, Kobayashi S, Sato M, Akutsu H, Okabe M, Mekada E, Sakakibara K, Miyado M, Umezawa A, Miyado K.: Possible involvement of CD81 in acrosome reaction of sperm in mice. Mol Reprod Dev. 2007.

Yamada Y, Sakurada K, Takeda Y, Gojo S, Umezawa A.: Single-cell-derived mesenchymal stem cells overexpressing Csx/Nkx2.5 and GATA4 undergo the stochastic cardiomyogenic fate and behave like transient amplifying cells. Exp Cell Res. 313(4): 698-706. 2007. AU is a corresponding author.

Sugiki T, Uyama T, Toyoda M, Morioka H, Kume S, Miyado K, Matsumoto K, Saito H, Tsumaki N, Takahashi Y, Toyama Y, Umezawa A.: Hyaline cartilage formation and enchondral ossification modeled with KUM5 and OP9 chondroblasts. J Cell Biochem. 100(5):1240-1254, 2007. AU is a corresponding author.

Tomita M, Mori T, Maruyama K, Zahir T, Ward M, Umezawa A, Young MJ.: A comparison of neural differentiation and retinal transplantation with bone marrow-derived cells and retinal progenitor cells. Stem Cells. 24(10):2270-2278, 2006.

Kato S, Matsubara M, Matsuo T, Mohri Y, Kazama I, Hatano R, Umezawa A, Nishimori K.: Leucine-rich repeat-containing G protein-coupled receptor-4 (LGR4, Gpr48) is essential for renal development in mice. Nephron Exp Nephrol. 104(2):e63-75. 2006.

Nagayoshi, K., Ohkawa, H., Yorozu, K., Higuchi, M., Higashi, S., Kubota, N., Fukui, H., Imai, N., Gojo, S., Hata, J., Kobayashi, Y., and Umezawa, A.: Increased mobilization of c-kit+ Sca-1+ Lin- (KSL) cells and colony-forming units in spleen (CFU-S) following de novo formation of a stem cell niche depends on dynamic, but not stable, membranous ossification. J. Cell Physiol. in press, AU is a corresponding author.

Fukuhara Y, Li XK, Kitazawa Y, Inagaki M, Matsuoka K, Kosuga M, Kosaki R, Shimazaki T, Endo H, Umezawa A, Okano H, Takahashi T, Okuyama T.: Histopathological and Behavioral Improvement of Murine Mucopolysaccharidosis Type VII by Intracerebral Transplantation of Neural Stem Cells. Mol Ther. 13(3): 548-555, 2006.

Mori, T., Kiyono, T., Imabayashi, H., Takeda, Y., Tsuchiya, K., Miyoshi, S., Makino, H., Matsumoto, H., Saito, H., Ogawa, S., Sakamoto, M., Hata, J-i, Umezawa, A.: Combination of hTERT and Bmi-1, E6 or E7 induce prolongation of the life span of bone marrow stromal cells from an elderly donor without affecting their neurogenic potential. Mol Cell Biol, 25: 5183-5195, 2005, AU is a corresponding author.

Terai, M., Uyama, T., Sugiki, T., Li, X-K., Umezawa, A., and Kiyono, T.: Immortalization of human fetal cells: The life span of umbilical-cord-blood-derived cells can be prolonged without manipulating p16INK4a/RB braking pathway. Mol. Biol. Cell, 16(3):1491-1499, 2005. AU is a corresponding author.

Matsumoto, S., Shibuyaa, I., Kusakari, K., Segawa, K., Uyama, T., Shimada, A., and Umezawa, A.: Membranous osteogenesis system modeled with KUSA-A1 mature osteoblasts. Biochim Biophys Acta., 1725 (1): 57-63, 2005, AU is a corresponding author.

Matsushita, K., Iwanaga, S., Oda, T., Kimura, K., Shimada, M., Sano, M., Umezawa, A., Hata, J., and Ogawa, S.: Interleukin-6/soluble interleukin-6 receptor complex reduces infarct size via inhibiting myocardial apoptosis. Lab Inv, 85(10): 1210-1223, 2005.

Lu, F.Z., Fujino, M., Kitazawa, Y., Uyama, T., Hara, Y., Funeshima, N., Jiang, J.Y., Umezawa, A., and Li, X.K.: Characterization and gene transfer in mesenchymal stem cells derived from human umbilical-cord blood. J Lab Clin Med. 146(5): 271-278, 2005.

Katagiri, Y., Kiyokawa, N., Nakamura, K., Takenouchi, H., Taguchi, T., Okita, H., Umezawa, A., and Fujimoto, J.: Laminin binding protein, 34/67 laminin receptor, carries stage-specific embryonic antigen-4 epitope defined by monoclonal antibody Raft.2, Biochem. Biophys. Res. Co., 332(4): 1004-1011, 2005.

Higuchi, A., Shindo, Y., Gomei, Y., Mori, T., Uyama, T., and Umezawa, A.: Cell separation between mesenchymal progenitor cells through porous polymeric membranes. J Biomed Mater Res B Appl Biomater,Jul;74(1):511-9.;2005

Kawashima N, Shindo K, Sakamoto K, Kondo H, Umezawa, A., Kasugai S, Perbal B, Suda H, Takagi M, Katsube K.: Molecular and cell biological properties of mouse osteogenic mesenchymal progenitor cells, Kusa. J Bone Miner Metab. 23 (2):123-133, 2005

Kuroda, M., Oikawa, K., Yoshida, K., Takeuchi, A., Tekeuchi, M., Usui, M., Umezawa, A., and Mukai, K.: Effects of 3-methylcholanthrene on the transcriptional activity and mRNA accumulation of the oncogene hWAPL. Cancer letter, 221: 21-28, 2005.

Tsuchiya, K., Mori, T., Chen, G., Ushida, T., Tateishi, T., Matsuno, T., Sakamoto, M., and Umezawa, A: Custom-shaping system for bone regeneration by seeding marrow stromal cells onto a web-like biodegradable hybrid sheet. Cell Tissue Res, 316: 141-153, 2004, AU is a corresponding author.

Umezawa, A.: Mesenchymal stem cells and epigenetics, Brain & Development, 26: 417-418, 2004

Sakurai, K., Iizuka, S., Shen, J-S., Meng, X-L., Mori, T., Umezawa, A., Ohashi, T., and Eto, Y.: Brain transplantation of genetically modified bone marrow stromal cells corrects CNS pathology and cognitive function in MPS VII mice. Gene Therapy, 11(19):1475-1481, 2004

Oikawa, K., Ohbayashi, T., Kiyono, T., Nishi, H., Isaka, K., Umezawa, A., Kuroda, M., and Mukai, K.: Expression of a Novel Human Gene, Human Wings Apart-Like (hWAPL), Is Associated with Cervical Carcinogenesis and Tumor Progression. Cancer Res, 64: 3545-3549, 2004

Takeda, Y., Mori, T., Imabayashi, H., Kiyono, T., Gojo, S., Miyoshi, S., Ita, M., Segawa, K., Ogawa, S., Sakamoto, M., Nakamura, S., and Umezawa, A.: "Can the life-span of human marrow stromal cells be prolonged by bmi-1, E6, E7, and/or telomerase without affecting cardiomyogenic differentiation?", J Gene Med, 6(8): 833-845, 2004. AU is a corresponding author.

Higuchi, A., Hamamura, A., Shindo, Y., Kitamura, H., Yoon, B-O., Mori, T., Uyama, T., and Umezawa, A.: Photon-modulated changes of cell attachments on poly(spiropyran-co-methylmethacrylate) membranes, Biomacromolecules, 5(5): 1770-1774, 2004.

Kato, Y., Imabayashi, H., Mori, M., Tani, T., Taniguchi, M., Umezawa, A., and Tsunoda, Y.: Developmental totipotency of tissue-specific stem cells from an adult mammal: Nuclear transfer of adult bone marrow mesenchymal stem cells. Biol Reprod, 70: 415-418, 2004

Sharov, A. A., Piao, Y., Matoba, R., Dudekula, D. B., Qian, Y., VanBuren, V., Falco, G., Martin, P. R., Stagg, C. A., Bassey, U. C., Wang, Y., Carter, M. G., Hamatani, T., Aiba, K., Akutsu, H., Sharova, L., Tanaka, T. S., Kimber, W. L., Yoshikawa, T., Jaradat, S. A., Pantano, S., Nagaraja, R., Boheler, K. R., Taub, D., Hodes, R. J., Longo, D. L., Schlessinger, D., Keller, J., Klotz, E., Kelsoe, G., Umezawa, A., Vescovi, A. L., Rossant, J., Kunath, T., Hogan, B. L. M., Curci, A., D'Urso, M., Kelso, J., Hide, W., and Ko, M. S. H.: Transcriptome analysis of mouse stem cells and early embryos, PLoS Biology, 1 (3): 410-419, 2003

Imabayashi, H., Mori, T., Gojo, S., Kiyono, T., Sugiyama, T., Irie, R., Isogai, T., Hata, J., Toyama, Y., and Umezawa, A.: Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis. Exp Cell Res, 288: 35-50, 2003, AU is a corresponding author.

Gojo, S., Gojo, N., Takeda, Y., Mori, T., Abe, H., Kyo, S., Hata, J., and Umezawa, A.: In vivo Cardiovasculogenesis by Direct Injection of Isolated Adult Mesenchymal Stem Cells. Exp Cell Res, 288: 51-59, 2003, AU is a corresponding author.

Gojo S, Umezawa A.: Plasticity of mesenchymal stem cells--regenerative medicine for diseased hearts. Hum Cell. 16(1):23-30, 2003.

Allan, E. H., Ho, P.W., Umezawa, A., Hata, J., Makishima, F., Gillespie, M. T., Martin, T. J.: Differentiation potential of a mouse bone marrow stromal cell line. J Cell Biochem., 90(1):158-169, 2003.

Shindo K, Kawashima N, Sakamoto K, Yamaguchi A, Umezawa A, Takagi M, Katsube K, Suda H.: Osteogenic differentiation of the mesenchymal progenitor cells, Kusa is suppressed by notch signaling. Exp Cell Res, 290(2):370-80, 2003

Matsushita, K., Okita, H., Suzuki, A., Shimoda, K., Fukuma, M., Yamada, T., Urano, F., Honda, T., Sano, M., Iwanaga, S., Ogawa , S., Hata, J., and Umezawa, A.: Islet cell hyperplasia in transgenic mice overexpressing EAT/mcl-1, a bcl-2 related gene. Mol Cell Endocr, 203 (1-2) : 105-116, 2003, AU is a corresponding author.

Yoneda S, Itoh D, Kuroda S, Kondo H, Umezawa A, Ohya K, Ohyama T, Kasugai S. The effects of enamel matrix derivative (EMD) on osteoblastic cells in culture and bone regeneration in a rat skull defect. J Periodontal Res. 38(3):333-342, 2003.

Fukuma, M., Okita, H., Hata, J., and Umezawa, A.: Up-regulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWS/ets protein in Ewing sarcoma. Oncogene, 22(1): 1-9, 2003. AU is a corresponding author.

Ochi, K., Chen, G., Ushida, T., Gojo, S., Segawa, K., Tai, H., Ueno, K., Ohkawa, H., Mori, T., Toyama, Y., Hata, J-i., and Umezawa, A.: The use of isolated mature osteoblasts in abundance acts as desired-shaped bone regeneration in combination with a modified poly DL-lactic- co-glycolic acid (PLGA)-collagen sponge. J. Cell. Physiol. 194:45-53, 2003, AU is a corresponding author.

Shibata R, Takata A, Hashiguchi A, Umezawa A, Yamada T, Hata J : Responsiveness of chemotherapy based on the histological type and WT1 mutation in bilateral Wilms tumor. Pathology international, 53(4): 214-220, 2003

Shibata, R., Umezawa, A., Takehara, K., Aoki, D., Nozawa, S., Hata, J.: Primary carcinosarcoma of the vagina, Pathol Int., 53(2):106-110, 2003

Itoh D, Yoneda S, Kuroda S, Kondo H, Umezawa A, Ohya K, Ohyama T, and Kasugai S.: Enhancement of osteogenesis on hydroxyapatite surface coated with synthetic peptide (EEEEEEEPRGDT) in vitro. J Biomed Mater Res. 62(2):292-298, 2002.

Shibata, R., Hashiguchi, A., Sakamoto, J., Yamada, T., Umezawa, A., and Hata, J.: Correlation between a specific Wilms tumor suppressor gene (Wt1) mutation and the histological findingz in Wilms tumor (WT), J Med Genet. 39(12):E83, 2002

Suzuki, S., Tanaka, K., Nogawa, S., Umezawa, A., Hata, J., and Fukuuchi, Y.: Expression of interleukin-6 in cerebral neurons and ovarian cancer tissue in Trousseau syndrome. Clin Neuropathol., 21 (5): 232-235, 2002

Ogawa, S., Matsumura, S., Yoshikawa, T., Satoh, T., Kumagai, H., Mitamura, H., Iwanaga, S., and Umezawa, A.: A case of dilated cardiomyopathy with end-stage heart failure treated by prolonged continuous hemodiafiltration. Keio J Med. 51 (3): 165-177, 2002

Yabe, H., Fukuma, M., Urano, F., Yoshida, K., Toyama, Y., Hata, J., and Umezawa, A.: Matrix Metalloproteinase (MMP)-1 and -3 expression in Ewing's sarcoma may be due to loss of accessibility of the MMP regulatory element to the specific fusion protein in vivo,. Biochem. Biophys. Res. Co., 293: 61-71, 2002 (Tables are corrected in BBRC, 295: 573-574, 2002), AU is a corresponding author.

Inoshita S, Takeda K, Hatai T, Terada Y, Sano M, Hata J, Umezawa A, Ichijo H: Phosphorylation and inactivation of myeloid cell leukemia 1 by JNK in response to oxidative stress. J Biol Chem. 277(46):43730-4, 2002.

Itoh D, Yoneda S, Kuroda S, Kondo H, Umezawa A, Ohya K, Ohyama T, Kasugai S. Enhancement of osteogenesis on hydroxyapatite surface coated with synthetic peptide (EEEEEEEPRGDT) in vitro. J Biomed Mater Res. 62(2):292-8, 2002.

Hakuno, D., Fukuda, D., Makino, S., Konishi, F., Tomita, Y., Manabe, T., Suzuki, Y., Umezawa, A. and Ogawa, S.: Bone marrow-derived regenerated cardiomyocytes (CMG cells) express functional adrenergic and muscarinic receptors. Circulation, 105: 380-386, 2002

Ohyama, M., Amagai, M., Tsunoda, K., Ota, T., Koyasu, S., Hata, J., Umezawa, A. and Nishikawa, T.: Immunologic and histopathologic characterization of active disease model mouse for pemphigus vulgaris. J Invest Dermatol, 118: 199-204, 2002

Kohyama, J., Abe, H., Shimazaki, T., Koizumi, A., Nakashima, K., Gojo, S., Taga, T., Okano, H., Hata, J. and Umezawa, A.: Brain from Bone: Efficient "meta-differentiation" of marrow stroma-derived mature osteoblasts to neurons with noggin or a demethylating agent. Differentiation (Special issue on stem cells) 68: 235-244, 2001, AU is a corresponding author.

Shinoda, K., Nakamura, Y., Matsushita, K., Shimoda, K., Okita, H., Fukuma, M., Yamada, T., Ohde, H., Oguchi, Y., Hata, J. and Umezawa, A. : Light-induced apoptosis is accelerated in transgenic retina overexpressing human EAT/mcl-1, an anti-apoptotic bcl-2-related gene. Br J Ophthalmol 85: 1237-1243, 2001, AU is a corresponding author.

Muto A, Kizaki M, Kawamura C, Matsushita H, Fukuchi Y, Umezawa A, Yamada T, Hata J, Hozumi N, Yamato K, Ito M, Ueyama Y, Ikeda Y.: A novel differentiation-inducing therapy for acute promyelocytic leukemia with a combination of arsenic trioxide and GM-CSF. Leukemia. 15(8):1176-84, 2001

Sano, M., Umezawa, A., Abe, H., Akatsuka, A., Nonaka, S., Shimizu, H., Fukuma, M., Hata, J-i.: EAT/mcl-1 expression in the human embryonal carcinoma cells undergoing differetiation and apoptosis. Exp Cell Res, 266 (1): 114-125, 2001

Fukuzawa, R., Umezawa, A., Morikawa, Y., Chang Kim, K., Nagai, T., Hata, J-i: Nesidioblastosis and mixed hamartoma of the liver in Beckwith-Wiedemann syndrome: a case study including analysis of H19 methylation and insulin-like growth factor 2 genotyping and imprinting. Pediatr Dev Pathol. 4(4):381-90, 2001

Hamatani, T., Sasaki, H., Ishihara, K., Hida, N., Maruyama, T., Yoshimura, Y., Hata, J-i., and Umezawa, A.: Epigenetic mark sequence of the H19 gene in human sperm. Biochim Biophys Acta. 1518(1-2):137-44, 2001, AU is a corresponding author.

Ochi, K., Nozaki, H., Tanaka, F., Kato, K., Fukuzawa, F., Sobue, G., Fukuuchi, F., Toyama, Y., Hata, J-i., and Umezawa, A.: Specific bisulfite modification of CTG triplet repeats of the androgen receptor gene, a gene associated with the triplet repeat disease X-linked spinal and bulbar muscular atrophy (Kennedy Disease), Neuroscience Research Communications, 28(1): 1-10, 2001, AU is a corresponding author.

Fukuchi, Y., Kizaki, M., Yamato, K., Kawamura, C., Umezawa, A., Hata, J-i., Nishihara, T. and Ikeda, Y.: Mcl-1, an early-induction molecule, modulates activin A-induced apoptosis and differentiation of CML cells. Oncogene, 20: 704-713, 2001

Sano, M., Umezawa, A., Suzuki, A., Shimoda, K., Fukuma, M. , and Hata, J-i: Involvement of EAT/mcl-1, an anti-apoptotic bcl-2 related gene, in murine embryogenesis and human development. Exp. Cell Res. 259(1):127-139, 2000.

Wakabayashi, K., Saito, H., Ebinuma, H., Saito, Y., Takagi, T., Nakamura, M., Umezawa, A., Hata, J., and Ishii, H.: Bcl-2 related proteins are dramatically induced at the early stage of differentiation in human liver cancer cells by a histone deacetylase inhibitor projecting an anti-apoptotic role during this period. Oncol Rep. 7(2):285-288, 2000

Kinjo, K., Kizaki, M., Muto, A., Fukuchi, Y., Umezawa, A., Yamato, K., Nishihara, T., Hata, J., Ito, M., Ueyama, Y., and Ikeda, Y.: Arsenic trioxide (As2O3)-induced apoptosis and differentiation in retinoic acid-resistant acute promyelocytic leukemia model in hGM-CSF-producing transgenic SCID mice. Leukemia, 14: 431-438, 2000

Suzuki, A., Umezawa, A., Sano, M., Nozawa, S., and Hata, J-i: Involvement of EAT/mcl-1, a bcl-2 related gene, in the apoptotic mechanisms underlying human placental development and maintenance. Placenta, 21(2):177-183, 2000

Yamada, T., Hashiguchi, A., Fukushima, S., Kakita, Y., Umezawa, A., Maruyama, T., and Hata, J-i.: Function of 90-kDa heat shock protein in cellular differentiation of human embryonal carcinoma cells. In Vitro Cell Dev Biol-Animal 36: 139-146, 2000

Okita, H., Umezawa, A., Fukuma, F., Ando, T., Urano, F., Sano, M., Nakata, Y., Mori, T., and Hata, J-i: Acute myeloid leukemia possessing jumping translocation is related to highly elevated levels of EAT/mcl-1, a Bcl-2 related gene with anti-apoptotic functions. Leukemia Res. 24(1): 73-77, 2000

Matsushita, K., Umezawa, A., Iwanaga, S., Oda, T., Okita, H., Kimura, K., Shimada, M., Tanaka, M., Sano, M., Ogawa, M., and Hata, J-i: The EAT/mcl-1 gene, an inhibitor of apoptosis, is up-regulated in the early stage of acute myocardial infarction. Biochim Biophys Acta. 1472(3):471-478, 1999.

Fukuchi, Y., Miyakawa, Y., Kizaki, M., Umezawa, A., Shimamura, K., Kobayashi, K, Kuramochi, T., Hata, J., Ikeda, Y., Tamaoki, N., Nomura, T., Ueyama, Y., and Ito. M.: Human acute myeloblastic leukemia-ascites model using the human GM-CSF- and IL-3-releasing transgenic SCID mice. Ann. Hematol. 78: 223-231, 1999

Negishi, M., Umezawa, A., Kanda, T., Oguma, T., Maruyama, H., Murata, M., Ohata, Y., Hiraishi, Y., Sugita, T., Kato, S, and Hata, J-i.: Identification of AZT-resistant HIV clone (subtype E) from tissues of the HIV autopsy suggests the infection route and alternative protocol of therapy. Keio J. Med. 48(1):44-52, 1999

Fukuzawa, R., Umezawa, A., Ochi, K., Urano, F., Ikeda, H., and Hata, J-i.: High frequency of inactivation of the imprinted H19 gene in "sporadic" hepatoblastoma. Int. J. Cancer, 82(4):490-497, 1999

Makino, S., Fukuda, K., Miyoshi, S., Konishi, F., Kodama, H., Pan, J., Sano, M., Takahashi, T., Hori, S., Abe, H., Hata, J-i, Umezawa, A. and Ogawa, S.Cardiomyocytes can be generated from marrow stromal cells in vitro. J. Clin. Invest. 103: 697-705, 1999; reviewed by J. Leiden

Kanno, Z., Shibata, T., Umezawa, A., Kasugai, S., OHYA, K., and SOMA, K. Intracellular calcium response in cultured bone cells under mechanical stress. Orthodontic Waves 58 (6): 389-395, 1999

Ando, T., Umezawa, A., Suzuki, A., Okita, H., Sano, M., Hiraoka, Y., Aiso, S., Saruta, T, and Hata, J. EAT/mcl-1, a member of the bcl-2 related genes, confers resistane to apoptosis induced by cis-diamine dichloroplatinum (II) in mouse p53-deficient fibroblast cells. Jpn J Cancer Res, 89 (12): 1326-1333, 1998

Ishida, S., Yoshida, K., Kaneko, Y., Tanaka, Y., Sasaki, Y., Urano, F., Umezawa, A., Hata, J-i., and Fujinaga, K.: The genomic breakpoint and chimeric transcripts in the EWS-E1AF gene fusion in Ewing sarcoma. Cytogenet and Cell Genet, 82: 278-283, 1998

Urano, F., Umezawa, A., Yabe, H., Hong, W., Yoshida, K., Fujinaga, K., and Hata, J-i.: Molecular analysis of Ewing's sarcoma: another fusion gene, EWS-E1AF, available for the diagnosis. Jpn J Cancer Res. 89: 703-711, 1998

Hiraoka, Y., Ogawa, M., Sakai, Y., Taniguchi, K., Fujii, T., Umezawa, A., Hata, J-i., and Aiso, S.: Isolation and expression of a human SRY-related cDNA, hSOX20. Biochim Biophy Acta, 1396(2): 132-137, 1998

Okita, H., Umezawa, A., Suzuki, A., and Hata, J-i.: Up-regulated expression of murine mcl1/EAT, a Bcl-2 related gene, in the early stage of differentiation of murine embryonal carcinoma cells and embryonic stem cells. Biochem Biophy Acta, Jul 9;1398(3):335-341, 1998

Fukuchi, Y., Kizaki, M., Kinjo, K., Awaya, N., Ito, M., Kawai, Y., Umezawa, A., Hata, J-i., Ueyama, Y., and Ikeda, Y.: Establishment of a retinoic acid-resistant human acute promyelocytic leukaemia (APL) model in human granulocyte-macrophage colony-stimulating factor (hGM-CSF) transgenic severe combined immunodeficiency (SCID) mice. Br J Cancer. Oct;78(7):878-84, 1998

Sato, H., Koide, T., Masuya, H., Wakana, S., Sagai, T., Umezawa, A., Ishiguro S., Tamai, M. and Shiroishi, T.: A new mutation Rim3 resembling Re den is mapped close to retinoic acid alpha (Rara) gene on mouse chromosome 11. Mamm Genome, 9(1): 20-25, 1998

Neznanov, N, Umezawa, A., and Oshima, R. G.: A regulatory element within a conding exon modulates keratin 18 gene expression in transgenic mice. J. Biol. Chem. 272(44): 27549-27557, 1997

Umezawa, A., Yamamoto, H., Rhodes, K., Klemsz, M. J., Maki, R. A., and Oshima, R. G.: The methylation of an ETS site in the intron enhancer of the keratin 18 gene participates in tissue specific repression. Mol. Cell. Biol., 17(9): 4885-4894, 1997.

Sugimoto, T., Umezawa, A., Hata, J-i.: Neurogenic potential of Ewing's sarcoma cells. Virchows Archiv, 430: 41-46, 1997

Rippe, R. A., Umezawa, A., Kimball, J. P., Breindl, M., and Brenner, D. A.: Binding of upstream stimulatory factor to an E-box in the 3'-flanking region stimulates alpha1(I) collagen gene transcription. J. Biol. Chem. 272: 1753-1760, 1997.

Akasaka, Y., Umezawa, A., Sugimoto, T., Suzuki, H., Kawamura, and Hata, J-i: Bone marrow stromal specific antigen during development: Its expression in embryonic hematopoietic tissues as well as in other developing tissues. Pathology Int. 46: 243-252, 1996

Umezawa, A., Maruyama, T., Inazawa, J., Imai, S-i., Takano, T., and Hata, J-i.: Induction of mcl1/EAT, Bcl-2 related gene, by retinoic acid or heat shock in the human embryonal carcinoma cells, NCR-G3. Cell Struc. Func., 21: 1-8, 1996

Urano, F., Umezawa, A., Hong, W., Kikuchi, H., and Hata, J-i.: A novel chimera gene between EWS and E1A-F, encoding the adenovirus E1A enhancer-binding protein, in extraosseous Ewing's sarcoma. Biochem. Biophys. Res. Co., 219: 608-612, 1996

Maruyama, T., Umezawa, A., Kusakari, S., Kikuchi, H., Nozaki, M., and Hata, J-i.: Heat shock induces differentiation of human embryonal carcinoma cells into trophectoderm lineage. Exp. Cell Res. 224: 123-127, 1996.

Nakano, T., Umezawa, A., Abe, H., Suzuki, N., Yamada, T., Nozawa, S., and Hata, J-I.: A Monoclonal Antibody Which Specifically Reacts With Human Embryonal Carcinomas, Spermatogonias and Oocytes Is Able To Induce Human EC Cell Death. Differentiation 58: 223-240, 1995

Pankov, R., Neznanov, N., Umezawa, A., and Oshima, R.G.: AP-1, ETS and transcriptional silencers regulate the retinoic acid-dependent induction of keratin 18 in embryonic cells. Mol. Cell. Biol. 14(12): 7744-7757, 1994.

Rhodes, K., Rippe, R.A., Umezawa, A., Nehls, M., Brenner, D.A., and Breindl, M.: DNA methylation represses the murine alpha 1(1) collagen promoter by an indirect mechanism. Mol. Cell. Biol. 14(9): 5950-5960, 1994.

Pankov, R., Umezawa, A., Maki, R., Der. C., Hauser, C., and Oshima, R.G.: Oncogenic activation of human keratin 18 transcription via the ras signal transduction pathway. Proc. Natl. Acad. Sci. USA 91:873-882, 1994.

Hata, J-I., Umezawa, A., Yamada, T., Yamazaki, K., and Abe, H.: Differentiation of human EC cells and expression of cyoskeletal proteins. Proceedings of the eighth international conference of the international society of differentiation (ISD) 80-83, 1994.

Tachibana, K., Takayama N., Matsuo, K., Kato, S., Yamamoto, K., Ohyama, K., Umezawa, A., Takano, T.: Allele-specific activation of myc oncogene in an atypical Burkitt lymphoma carrying translocation t(2;8) 250 kilobase pairs downstream. Gene 124: 231-237, 1993.

Matsuo, K., Ikeshima, H., Shimada K., Umezawa A., Hata, J-I., Maejima, K., Nojima, H., and Takano, T.: Expression of the rat calmodulin gene II in the central nervous system: a 294-base promoter and 68-base leader segment mediates neuron-specific gene expression in transgenic mice. Mol. Brain Res. 20: 9-20, 1993.

Umezawa, A., Maruyama, T., Segawa, K., Shadduck, R.K., Waheed, A., and Hata, J-I.: Multipotent marrow stromal cell line is able to induce hematopoiesis in vivo. J. Cell Physiol. 151: 197-205, 1992, AU is a corresponding author.

Kikuchi, H., Akasaka, Y., Nagai, T., Umezawa, A., Kato, S., and Hata, J-I.: Intragenic deletion of WT gene in Wilms tumor and their correlation with histology. Amer. J. Pathol. 140: 781-786, 1992.

Umezawa, A. and Hata, J-I.: Gap-junctional protein (alpha 1 gap junction or connexin43) is down-regulated at the transcriptional level during the adipocyte differentiation. Cell Struc. Func. 17: 177-184, 1992, AU is a corresponding author.

Tachibana, K., Umezawa, A., and Takano, T.: Detection of and characterization of mRNA and proteins encoded by human rab2 low molecular weight GTP-binding protein gene. Biochem. Int. 28: 181-189, 1992.

Hata, J-I., Fujimoto, J., Ishii, E., Umezawa, A., Kokai, Y., Matsubayashi, Y., Abe, H., Kusakari, S., Kikuchi, H., Yamada, T., and Maruyama, T.: Differentiation of human germ cell tumor cells in vivo and in vitro. Acta Histochem. Cytochem. 25: 563-576, 1992.

Hirose, H., Ooishi, S., Sugiura, S., Umezawa, A., and Hosoda, Y.: Fatal splenic rupture in anabolic steroid-induced peliosis in a patient with myelodysplastic syndrome. Brit. J. Hematol. 78: 128-129, 1991.

Umezawa, A., Tachibana, K., Harigaya, K., Kusakari, S., Kato, S., Watanabe, Y., and Takano, T.: Colony-stimulating factor 1 expression is down-regulated during the adipocyte differentiation of H-1/A marrow stromal cells and induced by cachectin/Tumor necrosis factor. Mol. Cell. Biol. 11: 920-927, 1991, AU is a corresponding author.

Umezawa, A., Yamada, T., Ogawa, S., Kuramochi, S., and Watanabe, Y.: Postmortem diagnosis of acute megakaryocyte leukemia: Usefulness of immunohistochemistry and tissue hemogram. Acta Pathol. Jpn. 40: 693-698, 1990, AU is a corresponding author.

Umezawa, A., Harigaya, K., and Watanabe, Y. : Gap-junctional communication of bone marrow stromal cells is resistant to irradiation in vitro. Exp. Hematol. 18: 1002-1007, 1990, AU is a corresponding author.

Tachibana, K., Umezawa, A., Kato, S., and Takano, T.: Nucleotide sequence of a new YPT1-related human cDNA which belongs to the ras gene superfamily. Nucl. Acid Res. 16: 10368, 1988.

Umezawa, A., Harigaya, K., and Watanabe, Y. : Bone marrow stromal cells lose their gap-junctional communication in vitro during the differentiation to adipocytes. Hematology Reviews & Communications 1: 277-283, 1987, AU is a corresponding author.