Dr. Steven R. Schmid will present the research opportunities that exist in the Civil, Mechanical and Manufacturing Innovation (CMMI) division of the National Science Foundation, with particular emphasis on research in advanced manufacturing and the Manufacturing Machines and Equipment Program that he directs. An overview of strategies and practices for effective proposal preparation will be discussed, as well as an outline of new opportunities. Dr. Schmid will also present a new development in the manufacturing sector: biomanufacturing. Biomanufacturing is potentially a very large and emerging field, ranging from the use of porous constructs in total joint replacements that facilitate hard tissue integration, to the manufacture of functional organs through three dimensional printing. There have been innumerable efforts to build tissues and organs in the laboratory but deployment of the new technologies is blocked by inability to translate laboratory success into manufacturing at scale, while satisfying safety, reliability, and certification issues. Biomanufacturing is perhaps the most fundamental new engineering specialization and has received significant recent interest.