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Stem and progenitor cells hold great promise for musculoskeletal regenerative medicine, given their ability to both produce functional tissues ex vivo as well as participate in endogenous repair. These cells are responsive to both soluble factors and biophysical cues that reside within their microenvironment. Ultimately, these cells sum this information to make decisions regarding lineage commitment and function. This seminar will detail how both ‘passive’ and ‘active’ materials can be applied to direct MSC fate decisions. Examples will include material modifications that alter cell signaling to control how cells sense the mechanics of the microenvironment, as well methods to ‘instrument’ the dynamic loading environment of musculoskeletal tissue to direct biofactor release to promote repair and regeneration.
Dr. Robert L. Mauck
Presented September 8, 2017
(rough footage)
About the Presenter
About the Presenter
Robert L. Mauck, PhD is the Mary Black Ralston Professor of Education and Research in Orthopaedic Surgery and Professor of Bioengineering at the University of Pennsylvania. His research program is focused on the engineering and mechanobiology of musculoskeletal tissues, with a particular interest in restoring articular cartilage, the knee meniscus, and the intervertebral disc. Dr. Mauck’s team uses mechanical and molecular analyses to explore native tissue structure function relationships, and employs this information to enhance the functional properties of engineered constructs through focused technology development. His work explores progenitor cell function and efficacy in a variety of biomaterial contexts and across multiple length scales, from subcellular biophysical properties to translation of engineered constructs in large animal models.
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