Copium: a portmanteau of the words "cope" and "opium" used to describe a fictional drug to help one deal with loss.

Frequently used in meme macro or .gif form featuring one-time alleged alt-right icon Pepe the Frog.

First spotted in text form in 2018 on  4chan (no, Keak Da Sneak's album does not count).
First spotted in meme form in 2019, also on 4chan. Popularized in 2020 (ah, the drama of US elections.)