Cytotoxic Chemotherapy

CELGEM vial (gemcitabine)

Dosage Adult: IV Advanced non-small cell lung cancer 1 g/m2 on days 1, 8 and 15 of each 28-day cycle. Pancreatic cancer 1 g/m2 once wkly for up to 7 wk followed by 1 wk of rest. Continue thereafter w/ once wkly infusions for 3 consecutive wk out of 4. Bladder cancer 1 g/m2 on days 1, 8 and 15 of each 28-day cycle. To be given before cisplatin. Breast cancer 1.25 g/m2 on days 1 and 8 of each 21-day cycle. Ovarian carcinoma 1 g/m2 on days 1 and 8 of each 21-day cycle. To be given before carboplatin.

Contraindications Concurrent radical radiotherapy; pregnancy, lactation; hypersensitivity.

Special Precautions Children, hepatic and renal impairment. May impair ability to drive or operate machinery. Discontinue on 1st sign of microangiopathic haemolytic anaemia. Prolonged infusion time (>60 minutes) and more frequent than wkly dosing may increase toxicity. Monitor CBC before every dose. Increased risk of haemolytic uraemic syndrome and/or thrombocytcpenic purpura which may lead to irreversible renal failure.

Adverse Drug Reactions Bone marrow suppression as manifested by leukopenia, thrombocytopenia, anaemia and myelosuppression. Mild GI effects; rashes; renal impairment, pulmonary toxicity, influenza-like symptoms; interstitial pneumonia, pulmonary oedema. Proteinuria, haematuria and haemolytic uraemic syndrome. Elevation of serum transaminase.

Potentially Fatal: Oesophagitis and pneumonitis when given with radical radiotherapy to the thorax.

Drug Interactions May increase the anticoagulant effect of warfarin when used together.

Manufacturer Alkem (Cytomed)

Contents gemcitabine.

CELGEM vial

200 mg x 1's (1332 INR)

1000 mg x 1's (6354 INR)

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