ANTICOAGULATION: QUESTION: .
With regard to anticoagulation, which of the following statements is/are true? .
a. Warfarin (coumadin) inhibits the activity of vitamin K-dependent factors (II, VII, IX, and X)
b. Heparin enhances the effect of antithrombin on thrombin-mediated conversion of fibrinogen to fibrin
c. Theoretically, 1.28mg of protamine neutralizes 1 mg of heparin
d. The effects of vitamin K reversal take 48hr
e. An INR of more than 1.5 is considered safe for operation