Antidiabetic Agents

Glimepiride

Indications Type 2 DM.

Dosage Adult: PO Initial: 1-2 mg/day. Maintenance: 4 mg/day. Max: 6 mg/day.

Administration Should be taken with food. (Take immediately before or during breakfast, or the 1st main meal of the day. Do not skip meals.)

Overdosage For action to be taken in the event of accidental overdose ...

Contraindications Diabetic ketoacidosis with or without coma.

Special Precautions Increased risk of CV mortality. Elderly; hepatic and renal impairment. Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in patients with CHF or hepatic cirrhosis. Monitor blood-glucose concentration. Pregnancy, lactation.

Adverse Drug Reactions Vomiting, GI pain, diarrhoea; pruritus, erythema, urticaria, morbilliform, maculopapular eruptions; leukopenia, agranulocytosis, thrombocytopenia, haemolytic anaemia, aplastic anaemia and pancytopenia; hyponatraemia; changes in accommodation, blurred vision, jaundice.

Drug Interactions NSAIDs, salicylates, sulphonamides, chloramphenicol, coumarin, probenecid, CYP2C9 inhibitors, fibric acid derivatives, pegvisomant, TCAs, MAOIs and β-adrenergic blockers may potentiate the hypoglycaemic action of glimepiride. Thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, oestrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, rifampicin, CYP2C9 inducers and isoniazid may reduce hypoglycaemic effect of glimepiride. May increase the serum levels of ciclosporin. Serum levels may be increased by fluconazole.

AMARYL

Manufacturer Sanofi Aventis

AMARYL film-coated tab

1 mg x 10's (63.15 INR)

2 mg x 10's (117.4 INR)

3 mg x 10's (125 INR)

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