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club format this course examines standard advanced topics in crystallography as well as aspects of the current literature. Topics may include refinement, approaches to the phase problem, Fourier transform methods, etc. ANALYSIS OF MACROMOLECULES (NOTE: Biophysics & Biophysical Chemistry and Macromolecular Structure and Function were merged) Course Type: Biophysics & Biophysical Chemistry Course Director: Dr. Dominique Frueh, dfrueh@jhmi.edu Telephone Number: 410-614-4719 Faculty: Drs. Frueh, L.M. Amzel, S. Bailey, J.M. Berger, B. Cole, T. Ha, J. Kavran, A. Lau, J. Sohn, C. Wolberger, B. Wu, and N. Zachara Availability/Duration: First quarter 6 hours per week Prerequisite(s): None Drop period: mid-point of the course Description: The course will cover (1) macromolecules, (2) physical chemical principles dictating their biological behavior, and (3) methods to study them. Macromolecular interactions and functions are interpreted through a framework that combines theoretical concepts with experimental illustrations thereof. Key methods include: X-ray crystallography, nuclear magnetic resonance, cryo-electron microscopy, mass spectrometry, absorption and emission spectroscopies, hydrodynamic methods, and single-molecule approaches. Lectures will focus on practical applications of the methods, experimental design, data collection, and elementary aspects of data analyses.
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