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and Silicone Implants. Cancer. 2010; 116:5584-91 McCarthy CM. Randomized controlled trials. Plast Reconstr Surg. 2011 Apr;127(4):1707-12. McCarthy CM, Vanlaeken N, Lennox P, Scott AM, Pusic AL. The efficacy of artecoll injections for the augmentation of nipple projection in breast reconstruction. Eplasty. 2010; 10:e7 McCarthy CM, Pusic AL, Kerrigan CL. Silicone breast implants and magnetic resonance imaging screening for rupture: Do U.S. Food and Drug Administration recommendations reflect an evidencebased practice approach to patient care? Plast Reconstr Surg. 2008; 121:1127-34 McCarthy CM, Pusic AL, Sclafani L, Buchanan C, Fey JV, Disa JJ, Mehrara BJ, Cordeiro PG. Breast cancer recurrence following prosthetic, postmastectomy reconstruction: Incidence, detection, and treatment. Plast Reconstr Surg. 2008; 121:381-88 McCarthy CM, Mehrara BJ, Riedel E, Davidge K, Hinson A, Disa JJ, Cordeiro PG, Pusic AL. Predicting complications following expander/implant breast reconstruction: An outcomes analysis based on preoperative clinical risk. Plast Reconstr Surg. 2008; 121:1886-92 Dr. McCarthy was hired after completing a Masters of Biostatistics for Clinical Research and brought with her expertise in advanced clinical research design and analysis. She subsequently designed and performed one of the first blinded, multi-center randomized trials in the setting of breast reconstructive surgery. The goal of this trial was to provide surgeons and patients alike with an unbiased understanding of the impact of acellular dermal matrices on postmastectomy TE/I reconstruction from a patient perspective and with this knowledge, to ultimately improve surgical care. Since that time, Dr. McCarthy has worked further to elucidate the determinants of patient satisfaction following postmastectomy reconstruction. Her current areas of interest include the systematic evaluation and management of patient expectations, an important predictor of patient satisfaction with elective breast reconstructive surgery. Dr. McCarthy serves as the Principal Investigator of the ‘PROFILE (Patient Registry and Outcomes for Breast Implants and Anaplastic Large Cell Lymphoma (ALCL) Etiology and Epidemiology) study’. Through this collaboration between the FDA and the ASPS, the possible link between women with breast implants and ALCL is currently being evaluated. 20 Babak J. Mehrara, MD Attending Surgeon Chief of Plastic and Reconstructive Surgery Plastic and Reconstructive Service, Memorial Sloan Kettering Cancer Center Professor of Surgery Weill Medical College of Cornell University Education: BS, Boston University M.D., Columbia University, New York, NY Residencies: New York University Medical Center New York University, Post-Doctoral Research Fellowship: UCLA Medical Center 21 Selected publications: Savetsky, IL, Torrisi, JS, Cuzzone, DA, Ghanta, S, Albano, N, Gardenier, JC, Joseph, W, and Mehrara BJ. Obesity increases inflammation and impairs lymphatic function in a mouse model of lymphedema. Am J Physiol Heart Circ Physiol. 2014 15; 307 (2): H165-72. Cuzzone, DA, Weitman, ES, Albano, NJ, Ghanta, S, Savetsky, IL, Gardenier, JC, Joseph, WJ, Torrisi, JS, Bromberg, JF, Olszewski, WL, Rockson, SG, and Mehrara BJ. IL-6 regulates adipose deposition and homeostasis in lymphedema. Am J Physiol Heart Circ Physiol, 2014 May; 306 (10):1426. Weitman, ES, Aschen, SZ, Farias-Eisner, G, Albano, N, Cuzzone, DA, Ghanta, S, Zampell, JC, Thorek, D, and Mehrara BJ. Obesity impairs lymphatic fluid transport and dendritic cell migration to lymph nodes. PLoS One. 2013 Aug 12(8): e70703 Avraham T, Zampell JC, Yan A, Elhadad S, Weitman ES, Rockson SG, Bromberg J, Mehrara BJ. Th2 differentiation is necessary for soft tissue fibrosis and lymphatic dysfunction resulting from lymphedema. FASEB J. 2013 Nov 27. Zampell JC, Yan A, Elhadad S, Avraham T, Weitman E, Mehrara BJ. CD4+ Cells Regulate Fibrosis and Lymphangiogenesis in Response to Lymphatic Fluid Stasis. PLoS One. 2013;7(11) Aschen S, Zampell JC, Elhadad S, Weitman E, De Brot M, Mehrara BJ. Regulation of adipogenesis by lymphatic fluid stasis: part II. Expression of adipose differentiation genes. Plast Reconstr Surg. 2012 Apr;129(4):838-47 Zampell JC, Aschen S, Weitman ES, Yan A, Elhadad S, De Brot M, Mehrara BJ. Regulation of adipogenesis by lymphatic fluid stasis: part I. Adipogenesis, fibrosis, and inflammation. Plast Reconstr Surg. 2012 Apr;129(4):825-34. Yan A, Avraham T, Zampell JC, Haviv YS, Weitman E, Mehrara BJ. Adipose-derived stem cells promote lymphangiogenesis in response to VEGF-C stimulation or TGF-β1 inhibition. Future Oncol. 2011 Dec;7(12):1457-73. Zampell JC, Yan A, Avraham T, Daluvoy S, Weitman ES, Mehrara BJ. HIF-1α coordinates lymphangiogenesis during wound healing and in response to inflammation. FASEB Babak Mehrara trained in microsurgery at UCLA and has an extensive experience in reconstruction with perforator flaps including DIEP and SGAP for breast reconstruction. As Chief of the Plastic and Reconstructive Surgical Service at Memorial Sloan Kettering, he oversees the clinical and research activities of the service. His basic science and clinical research interests overlap and he clinically applies liposuction, lymph node transfer and lymphatic bypass procedures to patients with lymphedema. His long term goal is to design novel methods including surgery and
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