replaces the document of the same name, last published in 2015. (Fertil Steril 2021;116:54–63. 2021 by American Society for Reproductive Medicine.) El resumen está disponible en Español al final del artículo. Discuss: You can discuss this article with its authors and other readers at https://www.fertstertdialog.com/posts/32465 I nvoluntary childlessness because of infertility can profoundly impact people’s lives, causing medical, social, economic, and psychologic harm. Furthermore, the impact of barriers in family building has implications well beyond the individual, negatively impacting the social structure and stability of extended families and their communities. According to the National Survey of Family Growth, approximately 7.4 million women in the United States or approximately 12.1% of women of reproductive age experience difficulty having children because of impaired fecundity (1). Approximately 9.4% of men are subfertile or nonsurgically sterile (2). For many of these people, safe and effective methods of addressing infertility are needed but are unaffordable or otherwise inaccessible. When a treatment gap or inequality systematically affects members of certain disadvantaged subgroups of the population, it is considered a health disparity (3). This opinion discusses disparities in access to and use of effective reproductive medical treatments in the United States, the causes of these disparities, ethical implications, and needed responses. Disparities in access to effective treatment in reproductive medicine are tied to many factors, including socioeconomic status, geography, race, ethnicity, religion, sexual orientation, gender identity, marital status, and conscious or unconscious discrimination (4). KEY POINTS Building a family is a basic human right. Infertility is recognized as a disease by the World Health Organization and the American Medical Association, among others. In the United States, as in many other countries, economic, racial, ethnic, geographic, and other disparities affect both access to fertility treatments and treatment outcomes. Economic factors are the chief contributors to disparities in access to effective treatment; however, social and cultural factors play a role as well, including individual or systemic discrimination that disadvantages certain people because of their race, ethnicity, sexual orientation, or gender identity. Further research is needed and encouraged to understand documented racial and ethnic disparities in treatment success and to improve treatment methods to reduce those disparities. It is the responsibility of all those providing reproductive and infertility care, including assisted reproductive technology, such as physicians, policy makers, and insurance providers, to actively and deliberately address and lessen the barriers to infertility care. Efforts should include increasing insurance coverage, reducing the economic and noneconomic burdens of treatment, improving public and physician attention to treatment disparities, and reaching and educating underserved populations and geographic areas. Received February 9, 2021; accepted February 11, 2021. Reprint requests: Ethics Committee, American Society for Reproductive Medicine, 1209 Montgomery Highway, Birmingham, Alabama 35216-2809 (E-mail: asrm@asrm.org). Fertility and Sterility® Vol. 116, No. 1, July 2021 0015-0282/$36.00 Copyright ©2021 American Society for Reproductive Medicine, Published by Elsevier Inc. https://doi.org/10.1016/j.fertnstert.2021.02.019 54 VOL. 116 NO. 1 / JULY 2021 The importance of reproduction in modern American life has been recognized by our legal system for many decades. At the height of World War II, the US Supreme Court declared procreation ‘‘one of the basic civil rights of man . fundamental to the very existence and survival of the race’’(5). Decades later, the Court reiterated the importance of reproduction, calling it ‘‘a major life activity’’ deserving of protection under the federal law prohibiting discrimination against persons with disabilities (6). The right of reproductive liberty in the United States is understood commonly at a minimum as an individual’s right to be free from governmental interference with his or her reproductive decision making, including choices about whether and when to form a family and to receive treatment for disease (7). Using a framework of reproductive justice, ideally society should strive for the complete well-being of women and girls and the full achievement of their human rights—including the right to have or refrain from having children (8). Legal and policy norms also reflect the importance of reproduction in a person’s life. In 2009, the World Health Organization (WHO), in conjunction with the International Committee for Monitoring Assisted Reproductive Technology, revised its glossary to acknowledge that infertility is ‘‘a disease of the reproductive system’’ (9). In 2017, the American Medical Association endorsed the WHO definition, while the International Glossary on Infertility and Fertility Care has gone further to include in its definition ‘‘impairment of a person’s capacity to reproduce either as an individual or with his/ her partner,’’ to recognize the reproductive challenges of lesbian, gay, bisexual, transgender, queer, and unpartnered individuals (10, 11). The Inter-American Court of Human