Lau, D. Shortle, and T. Woolf 22 BIOPHYSICS AND BIOPHYSICAL CHEMISTRY Availability/Duration: Two hours per week; second semester. Prerequisite(s): None Drop Period: 1 month Description: Lectures will offer an introduction to the mathematical aspects of computer representation and manipulation of macromolecules, as well as discussions of important topics in computational chemistry of macromolecules including forces and potential fields, molecular mechanics, electrostatics, Monte Carlo methods, homology modeling, docking, and other modeling topics. COMPUTER MODELING OF BIOLOGICAL MACROMOLECULES (LAB) Course Type: Other Department: Biophysics & Biophysical Chemistry Course Director: Dr. Mario Bianchet Telephone Number: 410-614-8221 Faculty: Dr. Mario A. Bianchet Availability/Duration: Two hours per week; second semester; limited enrollment Prerequisite(s): None Drop Period: 1 month ENROLLMENT LIMITED TO JHUSOM STUDENTS. Description: The laboratory course will familiarize students with practical aspects of molecular modeling. It teaches tools to create and manipulate computer generated models of biological-interest molecules. Techniques such as comparative modeling will be introduced. RESEARCH PROJECTS IN BIOCHEMISTRY, BIOPHYSICS AND MOLECULAR BIOLOGY Course Type: Basic Research Department: See below Course Director: All members of the BCMB Graduate Program Faculty: All members of the BCMB Graduate Program Drop Period: 1 month Description: (Jointly with all the Basic Sciences: Biological Chemistry, Biophysics and Biophysical Chemistry, Cell Biology, Molecular Biology, Neuroscience, Pharmacology, and Physiology). See Biological Chemistry for course description. TOPICS IN MACROMOLECULAR STRUCTURE AND FUNCTION Course Type: Other Department: Biophysics & Biophysical Chemistry Course Director: Dr. Bin Wu Telephone Number: 410-502-4201 Faculty: Departmental faculty Availability/Duration: One hour per week, second semester. Prerequisite(s): None Drop Period: 1 month ENROLLMENT LIMITED TO JHUSOM STUDENTS. Description: Seminar course covering a variety of topics involving the structure and function of proteins and nucleic acids. FUNDAMENTALS OF PROTEIN CRYSTALLOGRAPHY Course Type: Other Department: Biophysics & Biophysical Chemistry Course Director: Dr. L. Mario Amzel Telephone Number: 410-955-3955 Faculty: Drs. L. Mario Amzel, S. Bailey, M. Bianchet, S. Gabelli, J. Kavran, , and C. Wolberger 23 BIOPHYSICS AND BIOPHYSICAL CHEMISTRY Availability/Duration: Fourth quarter, two 75-minute lectures per week, alternates with “Advanced Topics in Protein Crystallography”; next offered in 2022. Prerequisite(s): Calculus and elementary physics, or consent of instructor Drop Period: 1 month Description: An introductory course designed to present the core knowledge and theoretical underpinnings of protein crystallography necessary to function in the laboratory. Assigned readings and problem sets will be given. PROTEINS AND NUCLEIC ACIDS Course Type: Other Department: Biophysics & Biophysical Chemistry Course Director: Dr. Sarah Woodson Telephone Number: 410-516-2015 Faculty: Drs. G. Bowman and S. Woodson Availability/Duration: Three hours per week; first semester Prerequisite(s): See course director Drop Period: 1 month ENROLLMENT LIMITED TO JHUSOM STUDENTS. Description: The structure of proteins, DNA and RNA and their functions in living systems. Students are required to participate in class discussions based on readings from primary scientific literature. Weekly problem sets include the analysis of molecular structures with Python and PyMOL scripts. Basic knowledge of UNIX and Python scripting required. PROTEINS AND NUCLEIC ACIDS II Course Type: Other Department: Biophysics & Biophysical Chemistry Course Director: Dr. James E. Berger Telephone Number: 410-955-7163 Faculty: Departmental Faculty Availability/Duration: Three hours per week; second semester Prerequisite(s): Nucleic Acids I Drop Period: 1 month ENROLLMENT LIMITED TO JHUSOM STUDENTS. Description: Critical reading and analysis of primary source literature is vital to scientific discourse and discovery. Students will be responsible for analyzing and critiquing papers in diverse topics and systems ranging from replication, transcription, translation to enzyme mechanism, drug resistance, innate immunity and signaling, Methods covered will include structural, biochemical, single molecule, single cell, and genomic approaches. Students will deliver analytic presentations on at least two groundbreaking papers relevant to these areas and will be expected to actively participate in class discussion of experimental methodology and logic of other papers assigned in the course. ADVANCED TOPICS IN PROTEIN CRYSTALLOGRAPHY Course Type: Other Department: Biophysics & Biophysical Chemistry Course Director: Departmental Faculty Telephone Number: 410-955-3955 Faculty: Departmental faculty Availability/Duration: Fourth quarter; alternates with "Fundamentals of Protein Crystallography" (interdivisional course); next offered in 2021. Prerequisite(s): Elementary crystallography Drop Period: 1 month 24 BIOPHYSICS AND BIOPHYSICAL CHEMISTRY Description: In a journal