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exosome biogenesis; alloimmunity. DR. SETH MARGOLIS The regulation of protein homeostasis in nervous system development and disease. DR. MOLLIE MEFFERT The regulation of neuronal gene expression in health and disease; impact of noncoding RNAs and RNA-binding proteins. DR. TAMARA O’CONNOR Molecular mechanisms of bacterial pathogenesis. DR. JOEL POMERANTZ Functional specificity and design of signal transduction pathways. DR. DANIEL RABEN Biochemistry and chemistry of lipids and lipid metabolizing enzymes involved in signaling cascades. DR. KAREN REDDY Understanding how the nuclear periphery and other subcompartments contribute to general nuclear architecture and to specific gene regulation. DR. GEORGE SACK Structure of human amyloid A proteins and their role in inflammation. DR. DAVID SHORTLE Computational approaches to refining protein models and de novo structure prediction. DR. MICHAEL WOLFGANG CNS control of metabolism; neuronal metabolism; neurochemistry. DR. NATASHA ZACHARA The role of intracellular glycosylation, O-GlcNAc, in survival signaling models of oxidative stress. 20 BIOMEDICAL ENGINEERING BIOMEDICAL ENGINEERING ME:210.699 Research: Biomedical Engineering has emerged as one of the most exciting interdisciplinary research fields in modern science. Biomedical engineers apply modern approaches from the experimental life sciences in conjunction with theoretical and computational methods from the disciplines of engineering, mathematics, and computer science. Our unique positioning within the Johns Hopkins Whiting School of Engineering and the Johns Hopkins School of Medicine provides students and faculty with opportunities to engage with other leading engineers, scientists, and physicians. Together, we are developing the disruptive technologies that will transform the practice of medicine and improve human health. Many of these technologies are currently used in the clinic to diagnose and treat diseases, from cardiac arrhythmias and sepsis to Alzheimer’s and cancer. Examples of these advances include new drug delivery methods, diagnostic imaging devices, artificial organs and orthopedic implants, prosthetic limbs, and patient-specific quantitative models of disease. A comprehensive list of faculty research is located on the department website www.bme.jhu.edu. Students interested in participating in a research project should contact the faculty member. ENROLLMENT LIMITED TO JHUSOM STUDENTS Courses: Courses offered by the Department of Biomedical Engineering are taught on the Homewood Campus. A full list of courses for each semester can be found on the Registrar’s Office website: http://web.jhu.edu/registrar. 21 BIOPHYSICS AND BIOPHYSICAL CHEMISTRY BIOPHYSICS AND BIOPHYSICAL CHEMISTRY ME:100.699 RESEARCH TOPICS IN BIOPHYSICS Course Type: Basic Research Department: Biophysics & Biophysical Chemistry Course Director: Dr. L. Mario Amzel Telephone Number: 410-955-3955 Faculty: Drs. L.M. Amzel, J. M. Berger, D. Frueh, T. J. Ha, A. Lau, J. Sohn, C. Wolberger, and J. Xiao Availability: This course is also available as an elective to medical students, to postdoctoral students, and to other qualified persons. Visiting medical students must follow JHUSOM quarter dates Description: The department has a particular focus in the molecular structures of proteins and nucleic acids, and their functional interrelationships. Research projects may be arranged with any departmental faculty member. Projects can be laboratory or library based, and of varying lengths. RESEARCH OPPORTUNITIES DR. AMZEL Structure enzymology of redox and phosphoryl transfer enzymes: MICAL, peptidyl amidating monooxygenase, PI3K, FPPS and Nudix hydrolases; channels and transporters; selected areas of structural thermodynamics. DR. BERGER Structural and mechanistic studies of protein/nucleic acid machines and assemblies that control DNA replication and chromosome organization. DR. FRUEH Structural and dynamic studies of active enzymatic systems by Nuclear Magnetic Resonance (NMR). Mechanisms of domain communication in non-ribosomal Peptide Synthetases. Development of NMR methods to study large and dynamic proteins. DR. HA Single-molecule detection and super-resolution imaging methods to study complex biological systems, including DNA/RNA/protein interactions, chromatin, and cellular mechanics. DR. LAU Structural thermodynamics of biomolecular association and conformational transitions, computational and experimental approaches. DR. SOHN Mechanistic studies of foreign-DNA sensing pathways in innate immunity. DR. WOLBERGER Structure-based mechanism of transcription regulation and ubiquitin signaling. DR WU Single-molecule microscopy/spectroscopy methods to study the molecular dynamics in live cells. DR. XIAO Dynamics of gene regulation and cell division using single-molecule fluorescence microscopy and live-cell analysis. COMPUTER MODELING OF BIOLOGICAL MACROMOLECULES-LECTURE Course Type: Other Department: Biophysics and Biophysical Chemistry Course Director: Dr. L. Mario Amzel Telephone Number: 410-955-3955 Faculty: Drs. L. M. Amzel, B. Garcia-Moreno, A.
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