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RELEVANT LEARNING OUTCOME:
(a) Outline the main stages of cell signaling – cellular response
🕐Estimated time for this section: 25 minutes
Signal Termination
Signal Termination
Importance:
Importance:
Prevents overstimulation
Maintains cell sensitivity
Mechanisms:
Mechanisms:
Ligand dissociation
GTP → GDP (G protein inactivation)
Dephosphorylation (phosphatases)
Removal of second messengers (cAMP, Ca²⁺)
Receptor sequestration / degradation
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