RELEVANT LEARNING OUTCOME:
(e) Describe the structural components of viruses, including enveloped viruses and bacteriophages, and interpret drawings and photographs of them.
Viruses are tiny infectious particles that range from 20 to 400 nm in diameter, and they can be examined only under an electron microscope.
Viruses can be classified by (i) morphological virus types, or (ii) host range.
(i) Four main morphological virus types
(ii) Host range (the type of host cells they can infect)
Bacterial viruses / Bacteriophages (e.g., T4 phage, lambda phage)
Animal viruses (e.g., influenze virus, Human Immunodeficiency Virus - HIV)
Plant viruses (e.g., TMV)
Viruses are not cells but simply nucleic acids enclosed in a protein capsid.
Why are viruses not regarded as cells?
They do not contain specialised structures within themselves that carry out different functions.
The basic structure of a virus consists of a protein capsid and a nucleic acid genome. Together, they make up a nucleocapsid. The unnarrated video below shows the structure and functions of these basic structures.
In addition to the nucleocapsid, some viruses have a phospholipid bilayer membrane that surrounds the the capsid. This viral envelope is derived from the host cell membrane and often have glycoproteins embedded in it.
Viruses that infect bacteria - bacteriophages - each has a head (the nucleocapsid) and a tail (= tail sheath + base plate + tail fibres). The tail is neat little 'machine' that helps the bacteriophage infect a bacterial cell through an 'attach-and-inject' mechanism!
Structure of a T4 bacteriophage
👁️🗨️Watch this unnarrated video on how a bacteriophage infects a bacterial cell and uses the host machinery to replicate its genome and components. For more details, see 'Genetics of Viruses'.
How can bacteriophages be useful? (see video description)
👁️🗨️Watch this video that provides an overview of what viruses are. This video also includes the modes of viral replication (lytic and lysogenic) that will be relevant in PU2's 'Genetics of Viruses'.
What are the structural differences among viruses?
Differences include:
presence or absence of a viral envelope
type of genetic material (ssRNA / dsRNA / ssDNA / dsDNA)
genome size (ranges from 1,000 - 100,000 nucleotides)
shapes of the capsid (helical / icosahedral / complex)
Ans: C
Structure 2 can only be the lipid bilayer (eliminating options A and D).
Glycoproteins tend to have a protruding structure due to the carbohydrate chain. Hence, 1 is the glycoprotein.
Attempt Qn 4 of the learning goals.