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RELEVANT LEARNING OUTCOME:
(e) Describe the development of cancer as a multi-step process that includes accumulation of mutations, angiogenesis and metastasis.
Multistep Model of Cancer Development
Multistep Model of Cancer Development
ποΈβπ¨οΈWatch the video to learn about how the development of cancer is a multi-step process that includes accumulations of gene mutations, angiogenesis and metastasis.
It is estimated that there needs to have accumulation of at least 6 different gene mutations in a single cell for it to become cancerous.
ποΈCheck Your Understanding: Learning Goals Checkpoint
ποΈCheck Your Understanding: Learning Goals Checkpoint
What are some genes that are involved in cancer development?
What are some genes that are involved in cancer development?
Proto-oncogenes
Tumour suppressor genes
Genes coding for telomerase
Genes coding for proteins involved in angiogenesis
Genes coding for proteins involved in metastasis
Why does oncogene lead to cancer development?
Why does oncogene lead to cancer development?
Promotes cell growth and division
Lead to over stimulation of cell cycle
Results in excessive cell division
Why does mutated tumour suppressor gene lead to cancer development?
Why does mutated tumour suppressor gene lead to cancer development?
Loss of ability for DNA repair
Loss of apoptosis during DNA damage
Loss of cell cycle control and inappropriate cell cycle progression
How does activation of telomerase gene lead to cancer development?
How does activation of telomerase gene lead to cancer development?
Telomerase catalyses addition of telomeric sequence
Delay degradation of telomere
Unlimited cell division
Difference between normal cells and cancer cells
Difference between normal cells and cancer cells
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