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RELEVANT LEARNING OUTCOME:
(d) Outline how insulin and glucagon regulate the concentration of blood glucose level through the respective tyrosine kinase receptor and G-protein linked receptor.
🕐Estimated time for this section: 25 minutes
Insulin & RTK Signalling
Insulin & RTK Signalling
Activation:
Activation:
Insulin binds RTK → dimerisation
Autophosphorylation of tyrosine residues
Transduction:
Transduction:
Activates relay proteins (IRS-1)
Involves PIP₃ + phosphorylation cascade
Leads to signal amplification
Response:
Response:
Increase glucose uptake (transporters inserted)
Increase glycogenesis
Decrease glycogenolysis & gluconeogenesis
👉 Overall effect: ↓ Blood glucose
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