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RELEVANT LEARNING OUTCOME:
(d) Outline how insulin and glucagon regulate the concentration of blood glucose level through the respective tyrosine kinase receptor and G-protein linked receptor.
🕐Estimated time for this section: 25 minutes
Glucagon & GPCR Signalling
Glucagon & GPCR Signalling
Activation:
Activation:
Glucagon binds GPCR → conformational change
G protein activated (GDP → GTP)
Transduction:
Transduction:
Activates adenylyl cyclase → cAMP
cAMP activates PKA → phosphorylation cascade
Response:
Response:
Increase glycogenolysis
Increase gluconeogenesis
Decrease glycogenesis
👉 Overall effect: ↑ Blood glucose
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