qeg907

\bibitem{qeg907} R.N. Tchuraev, A.V. Galimzyanov. Gene and epigene networks: Two levels in organizing the hereditary system // Journal of Theoretical Biology, Volume 259, Issue 4, 21 August 2009, Pages 659-669. doi:10.1016/j.jtbi.2009.03.034

Corresponding author. Tel.: +7 347 2352641; fax: +7 347 2356247.

Institute of Biology, Ufa Research Center, Russian Academy of Sciences, 69 Prospect Oktyabrya, Ufa 450054, Russia

Received 3 December 2007; revised 2 February 2009; accepted 25 March 2009. Available online 7 April 2009.

Abstract

Intracellular governing gene networks consisting of genes and regulatory bonds among them are considered as the first level in organizing the hereditary system. We give examples of both prokaryotic gene network that controls the development of the λ-phage and eukaryotic gene network that controls the early Drosophila ontogenesis. Using the method of generalized threshold models kinetic curves are shown for some gene products of these networks. Gene networks that govern ontogenetic processes can be envisioned as epigene networks, the networks of the subsequent level in organizing the hereditary systems. Based on the mathematical model our computer experiments show that even the simplest hypothetical two-epigene network is capable of ensuring divergent determination, conservation of determinate states and reproduction of the initial “zygotic” functional state. In addition, the experimental results are given on construction an artificial epigene.

Keywords: Dynamic equations; Models

Article Outline

1. Introduction

2. Gene networks

3. Epigenes and epigene networks

4. Conclusion

Acknowledgements

Appendix A. Appendix

Appendix B. Appendix

References

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