6th Edition

New to This Edition

New Co-Authors

Two new authors—visionary researchers as well as charismatic teachers—bring their considerable strengths to the Sixth Edition:

• Anthony Bretscher of Cornell University is known for identifying and characterizing new components of the actin cytoskeleton and elucidating their biological functions in relation to cell polarity and membrane traffic.

• Hidde Ploegh of the Massachusetts Institute of Technology has made major contributions to our understanding of immune system behavior, particularly in regard to the various tactics that viruses employ to evade our immune system responses and the ways our immune system responds.

Increased Clarity and Accessibility

In the Sixth Edition, the authors have intensified their commitment to accessibility, balancing their coverage of the latest scientific developments with students’ need for clear explanations of the fundamentals. In this edition:

• New concept-based heads outline key principles

• Improved chapter overviews give students the big picture and a solid foundation for what is to come

Exciting New Developments

A more complete listing of new scientific advances covered in the Sixth Edition can be found in the Annotated Table of Contents.Highlights include:

• Expanded coverage of proteomics, including organelle proteome profiling and advances in mass spectroscopy [Ch. 3]

• Expanded coverage of RNAi [Chs. 5, 8]

• Updated discussions of chromatin, including: structure and condensation [Ch. 6]; control of gene expression by chromatin remodeling [Ch. 7]; chromatin remodeling proteins and tumor development [Ch. 25]

• Evolution of chromosomes and the mito- chondrion [Ch. 6]

• Molecular models, including: pre-initiation complex and mediator complex [Ch. 7]; annular phospholipids [Ch.10]; Ca2+ ATPase [Ch. 11]; rhodopsin, transducin, and protein kinase A [Ch. 15]; myosin ATPase [Ch. 17]

• Latest advances in light and electron microscopy, including cryoelectron tomography [Ch. 9]

• Reactive Oxygen Species (ROS) [Ch.12]

• Role of supercomplexes in electron transport [Ch. 12]

• Human Epidermal Growth Factor Receptors (HERs) and treatment of cancer [Ch. 16]

• Myosin ATPase cycle [Ch. 17] [see Figure 17-24]

• Kinesin 1 ATPase cycle [Ch. 18]

• Epithelial-to-mesenchymal transition and cancer [Ch. 19]

• Use of retrovirus infection for tracing cell lineage [Ch. 21]

• Axon guidance molecules [Ch. 23]

• Cancer stem cells [Ch. 25]

• Use of DNA microarray analysis in tumor typing [Ch. 25]

Integrated Media featuring New Podcasts

New eBook fully integrates the complete contents of the text and its interactive media in a format that features a variety of helpful study tools. The eBook is easily accessible on any Internet-connected computer via a standard Web browser.

Podcasts narrated by the authors give students a deeper understanding of key figures in the text and a sense of the thrill of discovery.

Layered PowerPoint files of every figure, optimized for projection, which instructors can edit or project section by section, allowing students to follow underlying concepts.

Emphasis on Experiments

Molecular Cell Biology, Sixth Ediion provides a clear introduction to the techniques and experiments of scientists past and present, showing how important

discoveries led to the formation of the field’s key concepts. This experimental approach is evident not only in the text and figures, but also in the following:

• Students answer a research problem by looking at real experimental data in the thoroughly revised Analyze the Data problem at the end of each chapter.

Medical Relevance

The authors include medically relevant examples in every chapter, demonstrating the connection between basic research in molecular cell biology and human health and disease.

New Chapters

In addition to incorporating these and other exciting new developments, the Sixth Edition of Molecular Cell Biology also includes three new chapters:

• The Molecular Cell Biology of Development [22], presenting the fundamentals of development from fertilization through pattern formation, with increased focus on mammalian development.

• Nerve Cells [23], providing unified coverage of the cell biology of these specialized cells, including the latest advances in axonal pathfinding and sensory reception.

• Immunology [24], a capstone chapter applying principles of molecular cell biology to the vertebrate immune system.

New Organization

In consultation with over 100 professors of cell biology from around the country, the authors have revised the table of contents to unite related topics and mirror the organization of most courses.

Table of Contents

Part I Chemical and Molecular Foundations

1. Life Begins with Cells

2. Chemical Foundations

3. Protein Structure and Function

Part II Genetics and Molecular Biology

4. Basic Molecular Genetic Mechanisms

5. Molecular Genetic Techniques

6. Genes, Genomics, and Chromosomes

7. Transcriptional Control of Gene Expression

8. Post-transcriptional Gene Control

Part III Cell Structure and Function

9. Visualizing, Fractionating, and Culturing Cells

10. Biomembrane Structure

11. Transmembrane Transport of Ions and Small Molecules

12. Cellular Energetics

13. Moving Proteins into Membranes and Organelles

14. Vesicular Traffic, Secretion, and Endocytosis

15. Cell Signaling I: Signal Transduction and Short-term Cellular Responses

16. Cell Signaling II: Signaling Pathways that Control Gene Activity

17. Cell Organization and Movement I: Microfilaments

18. Cell Organization and Movement II: Microtubules and Intermediate Filaments

19. Integrating Cells into Tissues

Part IV Cell Growth and Development

20. Regulating the Eukaryotic Cell Cycle

21. Cell Birth, Lineage, and Death

22. The Molecular Cell Biology of Development

23. Nerve Cells

24. Immunology

25. Cancer

Preview Materials

Download Text Chapters in .PDF Format (you will need Adobe Acrobat Reader version 5.0 or above)

Chapter 13. Moving Proteins into Membranes and Organelles

http://www.whfreeman.com/files/0716776014/Ch13.pdf

Chapter 15. Signaling I: Signal Transduction and Short-term Cellular Effects

http://www.whfreeman.com/files/0716776014/Ch15.pdf

Chapter 17. Cell Organization and Movement I: Microfilaments

http://www.whfreeman.com/files/0716776014/Ch17.pdf

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About the Author(s)

Harvey Lodish is Professor of Biology and Professor of Bioengineering at the Massachusetts Institute of Technology and a member of the Whitehead Institute for Biomedical Research. Dr. Lodish is also a member of the National Academy of Sciences and the American Academy of Arts and Sciences and was President (2004) of the American Society for Cell Biology. He is well known for his work on cell membrane physiology, particularly the biosynthesis of many cell-surface proteins, and on the cloning and functional analysis of several cell-surface receptor proteins, such as the erythropoietin and TGF-ß receptors. His lab also studies hematopoietic stem cells and has identified novel proteins that support their proliferation. Dr. Lodish teaches undergraduate and graduate courses in cell biology and biotechnology.

Arnold Berk is Professor of Microbiology, Immunology and Molecular Genetics and a member of the Molecular Biology Institute at the University of California, Los Angeles. Dr. Berk is also a fellow of the American Academy of Arts and Sciences. He is one of the original discoverers of RNA splicing and of mechanisms for gene control in viruses. His laboratory studies the molecular interactions that regulate transcription nitiation in mammalian cells, focusing particular attention on transcription factors encoded by oncogenes and tumor suppressors. He teaches introductory courses in molecular biology and virology and an advanced course in cell biology of the nucleus.

Chris A. Kaiser is Professor and Head of the Department of Biology at the Massachusetts Institute of Technology. His laboratory uses genetic and cell biological methods to understand the basic processes of how newly synthesized membrane and secretory proteins are folded and stored in the compartments of the secretory pathway. Dr. Kaiser is recognized as a top undergraduate educator at MIT, where he has taught genetics to undergraduates for many years.

Monty Krieger is the Whitehead Professor in the Department of Biology at the Massachusetts Institute of Technology. For his innovative teaching of undergraduate biology and human physiology as well as graduate cell biology courses, he has received numerous awards. His laboratory has made contributions to our understanding of membrane trafficking through the Golgi apparatus and has cloned and characterized receptor proteins important for the movement of cholesterol into and out of cells, including the HDL receptor.

Matthew P. Scott is Professor of Developmental Biology, Genetics and Bioengineering at Stanford University School of Medicine and Investigator at the Howard Hughes Medical Institute. He is a member of the National Academy of Sciences and the American Academy of Arts and Sciences and a past president of the Society for Developmental Biology. He is known for his work in developmental biology and genetics, particularly in areas of cell-cell signaling and homeobox genes and for discovering the roles of developmental regulators in cancer. Dr. Scott teaches cell and developmental biology to undergraduate students, development and disease mechanisms to medical students and developmental biology to graduate students at Stanford University.

Anthony Bretscher is Professor of Cell Biology at Cornell University. His laboratory is well known for identifying and characterizing new components of the actin cytoskeleton, and elucidating their biological functions in relation to cell polarity and membrane traffic. For this work, his laboratory exploits biochemical, genetic and cell biological approaches in two model systems, vertebrate epithelial cells and the budding yeast. Dr. Bretscher teaches cell biology to graduate students at Cornell University.

Hidde Ploegh is Professor of Biology at the Massachusetts Institute of Technology and a member of the Whitehead Institute for Biomedical Research. One of the world’s leading researchers in immune system behavior, Dr. Ploegh studies the various tactics that viruses employ to evade our immune responses, and the ways in which our immune system distinguishes friend from foe. Dr. Ploegh teaches immunology to undergraduate students at Harvard University and MIT.

First Day of Class Materials

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