Shielding from gamma rays requires large amounts of mass, in contrast to alpha particles which can be blocked by paper or skin, and beta particles which can be shielded by foil. Gamma rays are better absorbed by materials with high atomic numbers and high density, although neither effect is important compared to the total mass per area in the path of the gamma ray. For this reason, a lead shield is only modestly better (20–30% better) as a gamma shield, than an equal mass of another shielding material such as aluminium, concrete, water or soil; lead's major advantage is not in lower weight, but rather its compactness due to its higher density. Protective clothing, goggles and respirators can protect from internal contact with or ingestion of alpha or beta emitting particles, but provide no protection from gamma radiation from external sources.
The higher the energy of the gamma rays, the thicker the shielding made from the same shielding material is required. Materials for shielding gamma rays are typically measured by the thickness required to reduce the intensity of the gamma rays by one half (the half value layer or HVL). For example gamma rays that require 1 cm (0.4″) of lead to reduce their intensity by 50% will also have their intensity reduced in half by 4.1 cm of granite rock, 6 cm (2½″) of concrete, or 9 cm (3½″) of packed soil. However, the mass of this much concrete or soil is only 20–30% greater than that of lead with the same absorption capability. Depleted uranium is used for shielding in portable gamma ray sources, but again the savings in weight over lead is modest, and the main effect is to reduce shielding bulk. In a nuclear power plant, shielding can be provided by steel and concrete in the pressure and particle containment vessel, while water provides a radiation shielding of fuel rods during storage or transport into the reactor core. The loss of water or removal of a "hot" fuel assembly into the air would result in much higher radiation levels than when kept under water.
All ionizing radiation causes similar damage at a cellular level, but because rays of alpha particles and beta particles are relatively non-penetrating, external exposure to them causes only[citation needed] localized damage, e.g. radiation burns to the skin. Gamma rays and neutrons are more penetrating, causing diffuse damage throughout the body (e.g. radiation sickness, cell's DNA damage, cell death due to damaged DNA, increasing incidence of cancer) rather than burns. External radiation exposure should also be distinguished from internal exposure, due to ingested or inhaled radioactive substances, which, depending on the substance's chemical nature, can produce both diffuse and localized internal damage. The most biological damaging forms of gamma radiation occur in the gamma ray window, between 3 and 10 MeV.