Immunological and Lymphoreticular Effects in Humans (ANA TEST)

ATSDR FOR UDMH SEE HEALTH EFFECTS 2.2.3.3 IMMUNOLOGICAL EFFECTS

2.2.3.3 Immunological and Lymphoreticular Effects.

Data regarding the immunological or lymphoreticular effects of hydrazines in humans after dermal exposure are limited to a single case study. A female laboratory worker intermittently exposed to an undetermined amount of hydrazine developed a lupus erythematosus-like disease (Reidenberg et al.1983). Symptoms included a photosensitive rash, fatigue, anthragias, and a breaking off of frontal hair. The subject also possessed antinuclear antibodies and antibody to DNA. A positive skin patch test response was obtained after a dermal challenge to hydrazine was administered. The study authors concluded that hydrazine can induce a lupus erythematosus-like disease in predisposed persons. In support of this view, a number of other hydrazine derivatives have been linked to the induction of lupus erythematosus in humans (Pereyo 1986).

As discussed in Section 2.2.3.2, dermal exposure to

hydrazine also produces allergic contact dermatitis in humans.

LINK TO ATSDR: http://www.atsdr.cdc.gov/toxprofiles/tp100.pdf