jsmc-10199

USE OF LIPID PROFILE AS MARKER OF SEVERITY IN PRE-ECLAMPSIA

Maryam Bakir Mahmood a

a  Department of Obstetrics and Gynaecology, College of Medicine, University of Sulaimani, Kurdistan Region, Iraq.  

Submitted: 25/3/2019; Accepted: 18/6/2019; Published: 21/6/2019

DOI Link: https://doi.org/10.17656/jsmc.10199 

ABSTRACT

Background 

Pre-eclampsia is the major cause of maternal morbidity and mortality, preterm birth, perinatal death, and intrauterine growth restriction. The incidence of pre-eclampsia globally varies widely from 5-15 percentages. Studies result’s find correlation of essential hypertension with alteration of serum cholesterol, triglycerides and HDL-C, various studies claim that abnormal lipid synthesis leading to increase of thromboxane level and the decrease of prostaglandin levels.

Objectives 

To assess changes in lipid profile in pre-eclampsia and if these changes can be used as a marker of severity of the condition.

Patients and Methods

Case-control Study at Sulaimani Maternity Teaching Hospital from 01. Feb. 2017 to 01. Aug. 2017, it includes 100 pregnant women divided into three groups. Control group who remained normotensive during study period and case group who subdivided to two group including those cases who developed mild and sever pre-eclampsia during study period.

Results

There was significant rise in the serum TC, TG, LDL and VLDL and decrease in HDL in pre-eclamptic groups compared to normal healthy pregnant women. When we compare patient with sever pre-eclampsia with patient with mild pre-eclampsia we found that women with sever pre-eclampsia has significantly higher level of TG (334.9 ± 97.8vs 250.2 ± 31.5) and VLDL (66.4 ± 19.8vs45.4 ± 12.7 only.

Conclusion

Maternal dyslipidemia early in second trimester may be an indicator for development of future pre-eclampsia.

KEYWORDS

Pre-eclampsia serum cholesterol, Triglyceride, Low-density lipoprotein, High-density lipoprotein, Very low-density lipoprotein.

References 

1. Susana Machado, Marta Neves, Luis Freitas, Mario Campos, Diagnosis, pathophysiology and management of preeclampsia: a review, Port J Nephrol . Hypert 2013; 27(3):153-161.

2. P  Rachael James, Catherine Nelson-Piercy, Management of Hypertension before, during and after pregnancy. Heart 2004; 90:1499-1504.

3. John M. Davison, Volker Homuth, ArunJeyabalan, Kirk   P.Conrad, S.Ananth Karumanchi, Susan Quaggin et al. New Aspects in the pathophysiology of Preeclampsia. Journal of American Society of Nephrology .2004; 15:2440-2448.

4. Punam D. Sachdeva, B.G.Patel, M.V. Bhatt. A Study of   Incidence   And   management   of   pregnancy induced hypertension in Central Gujarat, India. International Journal of Universal pharmacy and Life Sciences, Nov-Dec 2011; 1(3): 61-70.

5. Srinivas Reddy,T. Bikshapati, M.  Estari and M.Krishna Reddy. Obesity, Lipid profiles and prevalence of dyslipidemia amongst diabetic patients in Warangal. Asian Journal of Microbiology Biotechnology and Environmental Sciences. 2009, 11(4); 877-880.

6. Karl Winkler, Birgit Wetzka, Michael M. Hoffmann, Isolde Friedrich, Martina Kinner, Manfred W Baumstark et al. Triglyceride rich lipoproteins are associated with hypertension in preeclampsia. The Journal of Clinical Endocrinology and Metabolism.2003; 88(3):1162-1166.

7. Kashinakunti S.V., Sunitha H, Gurupadappa K, ManjulaR.Lipid Profile in preeclampsia-A Case control study. Journal of clinical and diagnostic Research. August 2010; 4:2748-51.

8. Biswajit Das, Shashi Kant Verma, Sumeru Samanta and Ayaz K. Mallick. Serum uric acid, triglycerides, total cholesterol and HDL-C measurements in pre-eclamptic women. International Journal of Pharma and Biosciences. July 2013; 4(3B):422-28.

9. Mutze S, Rudnik-Schoneborn S, Zerres K, Rath W. Genes and the pre-eclampsia syndrome. J Perinat Med. 2008; 36:38–5875-8.

10. Cekmen MB, Erbagci AB, Balat A, Duman C, Maral H, Ergen K, et al. Plasma lipid and lipoprotein concentrations in pregnancy induced hypertension. Clin Biochem. 2003;36(7):575-8. Sriniv

11. Srinivas Reddy, T.  Bikshapati, M.  Estari andM.Krishna Reddy. Obesity, Lipid profiles and prevalence  of  dyslipidemia  amongst  diabetic patients in Warangal. Asian Journal of Microbiology Biotechnology and Environmental Sciences. 2009, 11(4); 877-880.

12. M. Estari, AS Reddy, TBikshapathi, J Satyanarayana, L.Venkann MKrishna Reddy. The investigation of serum lipids and prevalence of dyslipidemia in urban adult population of Warangal district, Andhra Pradesh, India. Biology and Medicine, 2009.Vol 1 (2): 61-65.

13. Vidyabati RK, Davina H, Singh NK, Singh W Gyaneshwar. Serum β hcg and lipid profile in early second trimester as predictor of pregnancy induced hypertension. J obstet gynecol India 2010;60:44-50.

14. Baker AM, Klein RL, Haeri S, Boggess K. Maternal serum dyslipidemia occurs early in pregnancy in women with mild but not severe preeclampsia. Am J Obstet Gynecol. 2009; 4:201-93. 

15. Enquobahrie D, Williams M,Carole B, Frederick I, Luthy D. Plasma lipid concentration in early pregnancy and risk of pre eclampsia. Am J Obstet Gynecol. 2003; 189(6):106.

16. Cong K. J.; Wang T.T. and Lin G.R. lipid Metabolism and pregnancy induced Hypertension. Chung –Hua- Fu- Chan- Ko- Tsa- Chih, 1994; 29(11): 561-563, 697-698. 

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