jsmc-10146

THE RELATION BETWEEN HELICOBACTER PYLORI SEROPOSITIVITY AND IRON DEFICIENCY ANEMIA IN IRAQ-KURDISTAN-SULAIMANI CITY 

Nawshirwan G. Rashid a, Fidan F. Ahmed b, Basil K. Abdullah c, Ahmed Kh Yassin d and Mouroge Hashim Al Ani e

a Hiwa Hemato-Oncology Hospital/Sulaimani, Candidate of Kurdistani Board for Medical Specialties.

b Medical Laboratory Techniques Department, College of Technology/ Kirkuk, Foundation of Technical Education.

c Hiwa Hemato-Oncology Hospital/ Sulaimani, KBMS -Clinical Hematology program-Sulaimani Center.

d Program Director of KBMS- Clinical Hematology Program, Hawler Medical University.

e Clinical Hematology program, Erbil-Iraq. 

Submitted: 13/9/2017; Accepted: 5/1/2018; Published 15/4/2018

DOI Link: https://doi.org/10.17656/jsmc.10146 

ABSTRACT

Background 

Iron deficiency is the most common cause of anaemia worldwide and is seen in general practice. The cause of iron deficiency anemia changes in different age groups, whether due to blood loss, gastrointestinal causes or increase in body demand for iron.

Objectives 

This study was designed to determine any relation between Helicobacter pylori positive subjects serologically in Sulaymaniyah city/Iraqi Kurdistan with Iron deficiency anemia.

Patients and Methods

The current study enrolled one hundred twenty female volunteers (eighty female with positive H. pylori serology, either both or any one of IgG & IgM positive) and forty subjects with negative serology. Then, contributors divided to four groups according to the age. H. pylori was detected serologically by using anti-H. pylori IgG and IgM antibodies ELISA kit.

Results

Hemoglobin level, mean corpuscular volume, white blood cells, platelets counts, serum ferritin and total iron binding capacity, were measured. Hemoglobin level and mean corpuscular volume in all patients considerably decreased (P < 0.01) compared with all control groups. While, the outcome of white blood cells and platelets counts demonstrated no considerable changes in all patient groups compare with all control groups. Serum ferritin in all patient categories significantly reduced (P < 0.01) compared with all control groups. While, TIBC levels significantly raised in patient groups compare with control groups.

Conclusion

There is a relation between Helicobacter pylori positive serology and iron deficiency anemia in Kurdistan- Sulaimania city..

KEYWORDS

Iron deficiency anemia, H. pylori, Hiwa Hematology Hospital, Sulaimani.

References 

1. Provan, Drew, ABC of Clinical Haematology, 3rd Edition. BMJ Books. London, 2009

2. Oski F., Iron deficiency in infancy and childhood. N Engl J Med.,1993; 329(3): 190-193.

3. Blaser M.J., Atherton J.C., Helicobacter pylori persistence: biology and disease. J Clin Invest, 2004; 113:321-333.

4. Dubois S, Kearney DJ., Iron-deficiency anemia and Helicobacter pylori infection: a review of the evidence. Am J Gastroenterol 2005; 100:453–9.

5. Kenneth E.L., Helicobacter pylori Infection. N Engl J Med, 2010;362:1597-604.

6. Chey W. D., Wong B. C. Y., American College of Gastroenterology guideline on the management of Helicobacter pylori infection, Am J Gastroentrology,2007; 102 ( 8): 1808–1825.

7. Malfertheiner P., Megraud F., O’Morain C., Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report, 2007; Gut, vol. 56(6): 772–781.

8. Malfertheiner P., Megraud F., O’Morain CA., Management of Helicobacter pylori infection—the Maastricht IV/ Florence Consensus Report, 2012; Gut,vol. 61( 5): 646–664.

9. Stedman, Thomas Lathrop, Stedman’s medical dictionary, 28 edition, Philadelphia: Lippincott Williams & Wilkins, USA, c2006

10. Monzón H. , Montserrat F.,  Maria E., et al., Helicobacter pylori infection as a cause of iron deficiency anaemia of unknown origin,2013; J Gastroenterol. 14; 19(26): 4166–4171.

11. Jasem M. A., Alia A., Najah M. D., Jenan A. M., Iron deficiency in Helicobacter pylori infected patients in Baghdad, 2011; JMID. 1 (3): 114-117

12. Annibale B., Marignani M., Monarca B., Antonelli G., Marcheggiano A., Martino G., Reversal of iron deficiency anemia after Helicobacter pylori eradication in patients with asymptomatic gastritis,1999; J. Ann Intern Med;131:668–72.

13. Darvishi M., Katayoun Z., Hossein M., Kamyab A., Association between Iron Deficiency Anemia and Helicobacter Pylori Infection among Children Under Six Years in Iran, 2015; Acta Medica Iranica, 53(4):220-224.

14. Takezako N., Naohiro S., Akira T., et al., Lymphocytosis in Idiopathic Thrombocytopenic Purpura Patients Infected by Helicobacter pylori, 2013; OJBD. 3:32-35.

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